Essential Amino Acids for Substrate Binding and Catalysis of Human Flap Endonuclease 1 (∗)
Human flap endonuclease 1 (FEN-1) is a member of the structure-specific endonuclease
family and is involved in DNA repair. Eight restrictively conserved amino acids in FEN-1 …
family and is involved in DNA repair. Eight restrictively conserved amino acids in FEN-1 …
Nfe2l3 (Nrf3) deficiency predisposes mice to T-cell lymphoblastic lymphoma
We have previously generated mice deficient for Nfe213 (NF-E2 p45 related factor 3 or
Nrf3), a member of the cap 'n'collar family of basic-leucine zipper transcription factors. To …
Nrf3), a member of the cap 'n'collar family of basic-leucine zipper transcription factors. To …
Flap endonuclease 1 is a promising candidate biomarker in gastric cancer and is involved in cell proliferation and apoptosis
K Wang, C Xie, D Chen - International journal of …, 2014 - spandidos-publications.com
As a DNA repair protein, flap endonuclease 1 (FEN1), a structure-specific 5'nuclease, plays
pivotal roles in the maturation of Okazaki fragments, long-patch base excision repair …
pivotal roles in the maturation of Okazaki fragments, long-patch base excision repair …
[HTML][HTML] Structure of the DNA repair and replication endonuclease and exonuclease FEN-1: coupling DNA and PCNA binding to FEN-1 activity
Abstract Flap endonuclease (FEN-1) removes 5′ overhanging flaps in DNA repair and
processes the 5′ ends of Okazaki fragments in lagging strand DNA synthesis. The crystal …
processes the 5′ ends of Okazaki fragments in lagging strand DNA synthesis. The crystal …
Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation
N Wakabayashi, K Itoh, J Wakabayashi, H Motohashi… - Nature …, 2003 - nature.com
Transcription factor Nrf2 (encoded by Nfe2l2) regulates a battery of detoxifying and
antioxidant genes, and Keap1 represses Nrf2 function. When we ablated Keap1, Keap1 …
antioxidant genes, and Keap1 represses Nrf2 function. When we ablated Keap1, Keap1 …
Oncogenic NRF2 mutations in squamous cell carcinomas of oesophagus and skin
YR Kim, JE Oh, MS Kim, MR Kang… - The Journal of …, 2010 - Wiley Online Library
Nuclear factor erythroid‐related factor 2 (NRF2) encodes a transcription factor that induces
expression of cytoprotective proteins upon oxidative stress and oncogenic NRF2 mutations …
expression of cytoprotective proteins upon oxidative stress and oncogenic NRF2 mutations …
Structural basis for recruitment of human flap endonuclease 1 to PCNA
S Sakurai, K Kitano, H Yamaguchi, K Hamada… - The EMBO …, 2005 - embopress.org
Flap endonuclease‐1 (FEN1) is a key enzyme for maintaining genomic stability and
replication. Proliferating cell nuclear antigen (PCNA) binds FEN1 and stimulates its …
replication. Proliferating cell nuclear antigen (PCNA) binds FEN1 and stimulates its …
[HTML][HTML] Human flap endonuclease structures, DNA double-base flipping, and a unified understanding of the FEN1 superfamily
SE Tsutakawa, S Classen, BR Chapados, AS Arvai… - Cell, 2011 - cell.com
Summary Flap endonuclease (FEN1), essential for DNA replication and repair, removes
RNA and DNA 5′ flaps. FEN1 5′ nuclease superfamily members acting in nucleotide …
RNA and DNA 5′ flaps. FEN1 5′ nuclease superfamily members acting in nucleotide …
Genetic compensation induced by deleterious mutations but not gene knockdowns
Cells sense their environment and adapt to it by fine-tuning their transcriptome. Wired into
this network of gene expression control are mechanisms to compensate for gene dosage …
this network of gene expression control are mechanisms to compensate for gene dosage …
Differential DNA repair underlies mutation hotspots at active promoters in cancer genomes
Promoters are DNA sequences that have an essential role in controlling gene expression.
While recent whole cancer genome analyses have identified numerous hotspots of somatic …
While recent whole cancer genome analyses have identified numerous hotspots of somatic …