Flap endonuclease-1 (FEN-1), a 43-kDa protein, is a structure-specific and multifunctional
nuclease. It plays important roles in RNA primer removal of Okazaki fragments during DNA …

Background Drug resistance is a major challenge in cancer therapeutics. Abundant
evidence indicates that DNA repair systems are enhanced after repetitive chemotherapeutic …

The FEN1 nuclease functions during Okazaki fragment maturation in the eukaryotic cell. Like
many other proliferating cell nuclear antigen (PCNA)-binding proteins, FEN1 interacts with …

The Nrf2 pathway is frequently activated in human cancers through mutations in Nrf2 or its
negative regulator KEAP1. Using a cell-line-derived gene signature for Nrf2 pathway …

Highly rearranged and mutated cancer genomes present major challenges in the
identification of pathogenetic events driving the neoplastic transformation process. Here we …

Human flap endonuclease-1 (FEN-1) is a structure-specific endonuclease and exonuclease
which is essential for DNA replication and repair. We have cloned a human FEN-1 gene …

Common fragile sites (CFSs) are loci that preferentially exhibit metaphase chromosome
gaps and breaks after partial inhibition of DNA synthesis. The fragile site FRA3B, which lies …

Transformation and cancer growth are regulated by the coordinate actions of oncogenes
and tumor suppressors. Here, we show that the novel E3 ubiquitin ligase HACE1 is …

Abstract Flap EndoNuclease-1 (FEN-1) and the processivity factor proliferating cell nuclear
antigen (PCNA) are central to DNA replication and repair. To clarify the molecular basis of …

Abstract Nuclear factor (erythroid derived)-2 like 2 (NFE2L2), also known as nuclear factor
erythroid 2 (NF-E2)-related factor 2 (Nrf2), is a ubiquitous transcription factor essential for …