Involvement of IL-6 in the pathogenesis of inflammatory bowel disease and colon cancer
R Atreya, MF Neurath - Clinical reviews in allergy & immunology, 2005 - Springer
Inflammatory bowel disease (IBD), which consists of Crohn's disease and ulcerative colitis,
is defined as a chronic inflammation of the gastrointestinbal tract. The etiopathogenetic …
is defined as a chronic inflammation of the gastrointestinbal tract. The etiopathogenetic …
Interleukin-6 trans-signaling and colonic cancer associated with inflammatory bowel disease
S Rose-John, K Mitsuyama… - Current …, 2009 - ingentaconnect.com
The complex pathogenesis of inflammatory bowel disease (IBD) and inflammation induced
colon cancer involves a wide range of mediators including cytokines. Recent investigations …
colon cancer involves a wide range of mediators including cytokines. Recent investigations …
Master regulator of intestinal disease: IL-6 in chronic inflammation and cancer development
MJ Waldner, MF Neurath - Seminars in immunology, 2014 - Elsevier
IL-6 signaling is of central importance for the maintenance of chronic intestinal inflammation
in inflammatory bowel diseases (IBD) such as Crohn's disease and ulcerative colitis. IL-6 …
in inflammatory bowel diseases (IBD) such as Crohn's disease and ulcerative colitis. IL-6 …
Il-6 signaling in inflammatory bowel disease: pathophysiological role and clinical relevance
J Mudter, MF Neurath - Inflammatory bowel diseases, 2007 - academic.oup.com
Crohn's disease (CD) and ulcerative colitis (UC) are chronic inflammatory bowel diseases
(IBDs) occurring in the gut of genetically susceptible individuals independent of a specific …
(IBDs) occurring in the gut of genetically susceptible individuals independent of a specific …
Interleukin-6 trans-signaling in inflammatory bowel disease
K Mitsuyama, M Sata, S Rose-John - Cytokine & growth factor reviews, 2006 - Elsevier
The pathogenesis of inflammatory bowel disease (IBD) is complex, involving a wide range of
molecules including cytokines. Recent investigations support the important role of an …
molecules including cytokines. Recent investigations support the important role of an …
A potential role of IL-6/IL-6R in the development and management of colon cancer
Colorectal cancer (CRC) is the third most frequent cancer worldwide and the second
greatest cause of cancer deaths. About 75% of all CRCs are sporadic cancers and arise …
greatest cause of cancer deaths. About 75% of all CRCs are sporadic cancers and arise …
Cytokines: from gut inflammation to colorectal cancer
MC Fantini, F Pallone - Current drug targets, 2008 - ingentaconnect.com
Colorectal cancer represents a life-threatening complication of inflammatory bowel
diseases. Statistics indicate that the risk to develop colorectal cancer is higher in patients …
diseases. Statistics indicate that the risk to develop colorectal cancer is higher in patients …
Signaling molecules: the pathogenic role of the IL-6/STAT-3 trans signaling pathway in intestinal inflammation and in colonic cancer
R Atreya, MF Neurath - Current drug targets, 2008 - ingentaconnect.com
Although the precise etiology of inflammatory bowel diseases (IBD) still remains unclear,
considerable progress has been made in the identification of novel signal transduction …
considerable progress has been made in the identification of novel signal transduction …
STAT3-activating cytokines: a therapeutic opportunity for inflammatory bowel disease?
PM Nguyen, TL Putoczki, M Ernst - Journal of interferon & cytokine …, 2015 - liebertpub.com
The gastrointestinal tract is lined by a single layer of epithelial cells that secrete mucus
toward the lumen, which collectively separates the immune sentinels in the underlying …
toward the lumen, which collectively separates the immune sentinels in the underlying …
More than a sidekick: the IL-6 family cytokine IL-11 links inflammation to cancer
T Putoczki, M Ernst - Journal of leukocyte biology, 2010 - academic.oup.com
Review discusses newly emerging role for IL-11 in inflammation-associated cancers of the
gastrointestinal tract. IL-11, a member of the IL-6 family of cytokines, exerts pleiotropic …
gastrointestinal tract. IL-11, a member of the IL-6 family of cytokines, exerts pleiotropic …
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