Mycobacterium tuberculosis infects two billion people across the globe, and results in 8–9
million new tuberculosis (TB) cases and 1–1.5 million deaths each year. Most patients have …

The outcome of an encounter with Mycobacterium tuberculosis (Mtb) depends on the
pathogen's ability to adapt to the variable immune pressures exerted by the host …

Molecular epidemiological assessments, drug treatment optimization, and development of
immunological interventions all depend on understanding pathogen adaptation and genetic …

Genetic differences among mammalian hosts and among strains of Mycobacterium
tuberculosis (Mtb) are well-established determinants of tuberculosis (TB) patient outcomes …

Mycobacterium tuberculosis (M. tb.) infection leads to over 1.5 million deaths annually,
despite widespread vaccination with BCG at birth. Causes for the ongoing tuberculosis …

Tuberculosis (TB) is a heterogenous disease in humans with individuals exhibiting a wide
range of susceptibility. This heterogeneity is not captured by standard laboratory mouse …

Tuberculosis, mainly caused by the pathogenic bacterium Mycobacterium tuberculosis,
remains an inestimable public health problem, despite the established use of the Bacillus …

Pulmonary tuberculosis (TB) is caused by Mycobacterium tuberculosis in susceptible
humans. Here, we infected Diversity Outbred (DO) mice with∼ 100 bacilli by aerosol to …

Host genetics plays an important role in determining the outcome of Mycobacterium
tuberculosis infection. We previously found that Collaborative Cross (CC) mouse strains …

Although mouse infection models have been extensively used to study the host response to
Mycobacterium tuberculosis, their validity in revealing determinants of human tuberculosis …