the emerging role of genetics in precision medicine for patients with non‐alcoholic steatohepatitis
B Carlsson, D Lindén, G Brolén… - Alimentary …, 2020 - Wiley Online Library
Background Non‐alcoholic steatohepatitis (NASH) is a severe form of non‐alcoholic fatty
liver disease (NAFLD) characterised by liver fat accumulation, inflammation and progressive …
liver disease (NAFLD) characterised by liver fat accumulation, inflammation and progressive …
[HTML][HTML] Pnpla3 silencing with antisense oligonucleotides ameliorates nonalcoholic steatohepatitis and fibrosis in Pnpla3 I148M knock-in mice
D Lindén, A Ahnmark, P Pingitore, E Ciociola… - Molecular …, 2019 - Elsevier
Objective Nonalcoholic fatty liver disease (NAFLD) is becoming a leading cause of
advanced chronic liver disease. The progression of NAFLD, including nonalcoholic …
advanced chronic liver disease. The progression of NAFLD, including nonalcoholic …
Genetics and epigenetics of NAFLD and NASH: Clinical impact
Non-alcoholic fatty liver disease (NAFLD) is now recognised as the most common liver
disease worldwide. It encompasses a broad spectrum of conditions, from simple steatosis …
disease worldwide. It encompasses a broad spectrum of conditions, from simple steatosis …
[HTML][HTML] Non-alcoholic fatty liver disease: a narrative review of genetics
CJ Danford, Z Yao, ZG Jiang - Journal of biomedical research, 2018 - ncbi.nlm.nih.gov
Non-alcoholic fatty liver disease (NAFLD) is now the most common cause of chronic liver
diseases worldwide. It encompasses a spectrum of disorders ranging from isolated hepatic …
diseases worldwide. It encompasses a spectrum of disorders ranging from isolated hepatic …
Comprehensive molecular mechanisms and clinical therapy in nonalcoholic steatohepatitis: an overview and current perspectives
M Yan, S Man, L Ma, W Gao - Metabolism, 2022 - Elsevier
Our understanding of nonalcoholic steatohepatitis (NASH) pathophysiology continues to
advance rapidly. Given the complexity of the pathogenesis of NASH, the field has moved …
advance rapidly. Given the complexity of the pathogenesis of NASH, the field has moved …
PNPLA3 as a therapeutic target for fatty liver disease: the evidence to date
A Cherubini, E Casirati, M Tomasi… - Expert Opinion on …, 2021 - Taylor & Francis
Introduction An interaction between metabolic triggers and inherited predisposition
underpins the development and progression of non alcoholic fatty liver disease (NAFLD) …
underpins the development and progression of non alcoholic fatty liver disease (NAFLD) …
[PDF][PDF] The rs2294918 E434K variant modulates patatin‐like phospholipase domain‐containing 3 expression and liver damage
The patatin‐like phosholipase domain‐containing 3 (PNPLA3) rs738409 polymorphism
(I148M) is a major determinant of hepatic fat and predisposes to the full spectrum of liver …
(I148M) is a major determinant of hepatic fat and predisposes to the full spectrum of liver …
Genetic factors in the pathogenesis of nonalcoholic fatty liver and steatohepatitis
P Dongiovanni, S Romeo… - BioMed research …, 2015 - Wiley Online Library
Liver fat accumulation generally related to systemic insulin resistance characterizes
nonalcoholic fatty liver disease (NAFLD), which in the presence of nonalcoholic …
nonalcoholic fatty liver disease (NAFLD), which in the presence of nonalcoholic …
NAFLD: genetics and its clinical implications
Worldwide non-alcoholic fatty liver disease (NAFLD) is recognized as the most common type
of liver disease and its burden increasing at an alarming rate. NAFLD entails steatosis …
of liver disease and its burden increasing at an alarming rate. NAFLD entails steatosis …
[HTML][HTML] Tumor necrosis factor-α signaling in nonalcoholic steatohepatitis and targeted therapies
S Lu, Y Wang, J Liu - Journal of Genetics and Genomics, 2022 - Elsevier
Nonalcoholic steatohepatitis (NASH), an inflammatory subtype of nonalcoholic fatty liver
disease (NAFLD), is featured by significantly elevated levels of various pro-inflammatory …
disease (NAFLD), is featured by significantly elevated levels of various pro-inflammatory …