Regeneration of spinal cord connectivity through stem cell transplantation and biomaterial scaffolds

H Katoh, K Yokota, MG Fehlings - Frontiers in cellular neuroscience, 2019 - frontiersin.org
Significant progress has been made in the treatment of spinal cord injury (SCI). Advances in
post-trauma management and intensive rehabilitation have significantly improved the …

Current concepts of biomaterial scaffolds and regenerative therapy for spinal cord injury

H Suzuki, Y Imajo, M Funaba, H Ikeda… - International Journal of …, 2023 - mdpi.com
Spinal cord injury (SCI) is a catastrophic condition associated with significant neurological
deficit and social and financial burdens. It is currently being managed symptomatically, with …

Recent advances in the regenerative approaches for traumatic spinal cord injury: materials perspective

WA Abbas, ME Ibrahim, M El-Naggar… - ACS Biomaterials …, 2020 - ACS Publications
Spinal cord injury (SCI) is a devastating health condition that may lead to permanent
disabilities and death. Understanding the pathophysiological perspectives of traumatic SCI …

Advances in regenerative therapies for spinal cord injury: a biomaterials approach

M Tsintou, K Dalamagkas… - Neural regeneration …, 2015 - journals.lww.com
Spinal cord injury results in the permanent loss of function, causing enormous personal,
social and economic problems. Even though neural regeneration has been proven to be a …

[HTML][HTML] Advanced approaches to regenerate spinal cord injury: the development of cell and tissue engineering therapy and combinational treatments

J Saremi, N Mahmoodi, M Rasouli, FE Ranjbar… - Biomedicine & …, 2022 - Elsevier
Spinal cord injury (SCI) is a central nervous system (CNS) devastate event that is commonly
caused by traumatic or non-traumatic events. The reinnervation of spinal cord axons is …

Advances in biomaterial‐based spinal cord injury repair

H Shen, C Fan, Z You, Z Xiao… - Advanced Functional …, 2022 - Wiley Online Library
Spinal cord injury (SCI) often leads to the loss of motor and sensory functions and is a major
challenge in neurological clinical practice. Understanding the pathophysiological changes …

Biomaterial-supported cell transplantation treatments for spinal cord injury: challenges and perspectives

S Liu, T Schackel, N Weidner… - Frontiers in cellular …, 2018 - frontiersin.org
Spinal cord injury (SCI), resulting in para-and tetraplegia caused by the partial or complete
disruption of descending motor and ascending sensory neurons, represents a complex …

Biomaterials combined with cell therapy for treatment of spinal cord injury

Š Kubinová, E Syková - Regenerative medicine, 2012 - Taylor & Francis
Spinal cord injury (SCI) is a devastating traumatic injury resulting in paralysis or sensory
deficits due to tissue damage and the poor ability of axons to regenerate across the lesion …

Repair of injured spinal cord using biomaterial scaffolds and stem cells

B Shrestha, K Coykendall, Y Li, A Moon… - Stem cell research & …, 2014 - Springer
The loss of neurons and degeneration of axons after spinal cord injury result in the loss of
sensory and motor functions. A bridging biomaterial construct that allows the axons to grow …

Strategies and prospects of effective neural circuits reconstruction after spinal cord injury

B Yang, F Zhang, F Cheng, L Ying, C Wang, K Shi… - Cell Death & …, 2020 - nature.com
Due to the disconnection of surviving neural elements after spinal cord injury (SCI), such
patients had to suffer irreversible loss of motor or sensory function, and thereafter enormous …