Advancing untargeted metabolomics using data-independent acquisition mass spectrometry technology
Metabolomics quantitatively measures metabolites in a given biological system and
facilitates the understanding of physiological and pathological activities. With the recent …
facilitates the understanding of physiological and pathological activities. With the recent …
MetDIA: targeted metabolite extraction of multiplexed MS/MS spectra generated by data-independent acquisition
With recent advances in mass spectrometry, there is an increased interest in data-
independent acquisition (DIA) techniques for metabolomics. With DIA technique, all …
independent acquisition (DIA) techniques for metabolomics. With DIA technique, all …
Eight key rules for successful data‐dependent acquisition in mass spectrometry‐based metabolomics
E Defossez, J Bourquin, S von Reuss… - Mass Spectrometry …, 2023 - Wiley Online Library
In recent years, metabolomics has emerged as a pivotal approach for the holistic analysis of
metabolites in biological systems. The rapid progress in analytical equipment, coupled to the …
metabolites in biological systems. The rapid progress in analytical equipment, coupled to the …
Mass spectrometry-based technologies for high-throughput metabolomics
The metabolome is composed of a vast number of small-molecule metabolites that exhibit a
diversity of physical and chemical properties and exist over a wide dynamic range in …
diversity of physical and chemical properties and exist over a wide dynamic range in …
DecoMetDIA: deconvolution of multiplexed MS/MS spectra for metabolite identification in SWATH-MS-based untargeted metabolomics
SWATH-MS-based data-independent acquisition mass spectrometry (DIA-MS) technology
has been recently developed for untargeted metabolomics due to its capability to acquire all …
has been recently developed for untargeted metabolomics due to its capability to acquire all …
DaDIA: Hybridizing data-dependent and data-independent acquisition modes for generating high-quality metabolomic data
Existing data acquisition modes such as full-scan, data-dependent (DDA), and data-
independent acquisition (DIA) often present limited capabilities in capturing metabolic …
independent acquisition (DIA) often present limited capabilities in capturing metabolic …
Advances in mass spectrometry-based metabolomics for investigation of metabolites
JL Ren, AH Zhang, L Kong, XJ Wang - RSC advances, 2018 - pubs.rsc.org
Metabolomics is the systematic study of all the metabolites present within a biological
system, which consists of a mass of molecules, having a variety of physical and chemical …
system, which consists of a mass of molecules, having a variety of physical and chemical …
Current state of the art of mass spectrometry-based metabolomics studies–a review focusing on wide coverage, high throughput and easy identification
Metabolomics aims at the comprehensive assessment of a wide range of endogenous
metabolites and attempts to identify and quantify the attractive metabolites in a given …
metabolites and attempts to identify and quantify the attractive metabolites in a given …
MET-IDEA: data extraction tool for mass spectrometry-based metabolomics
CD Broeckling, IR Reddy, AL Duran, X Zhao… - Analytical …, 2006 - ACS Publications
A current and significant limitation to metabolomics is the large-scale, high-throughput
conversion of raw chromatographically coupled mass spectrometry datasets into organized …
conversion of raw chromatographically coupled mass spectrometry datasets into organized …
Enhanced MS/MS coverage for metabolite identification in LC-MS-based untargeted metabolomics by target-directed data dependent acquisition with time-staggered …
Metabolite identification is one of the major bottlenecks in liquid chromatography-mass
spectrometry (LC-MS)-based untargeted metabolomics owing to the difficulty of acquiring …
spectrometry (LC-MS)-based untargeted metabolomics owing to the difficulty of acquiring …