Tumor necrosis factor-α in heart failure: an updated review

SM Schumacher, SV Naga Prasad - Current cardiology reports, 2018 - Springer
Abstract Purpose of the Review Proinflammatory cytokines are consistently elevated in
congestive heart failure. In the current review, we provide an overview on the current …

Proinflammatory cytokines in heart failure: double-edged swords

M Hedayat, MJ Mahmoudi, NR Rose, N Rezaei - Heart failure reviews, 2010 - Springer
Increased circulating and intracardiac levels of proinflammatory cytokines have been
associated with chronic heart failure. Following an initial insult, the increased production of …

Tumour necrosis factor-α and the failing heart: pathophysiology and therapeutic implications

S von Haehling, EA Jankowska, SD Anker - Basic Research in Cardiology, 2004 - Springer
■ Abstract Immune activation plays a significant role in the development and progression of
chronic heart failure (CHF). Indeed, pro-inflammatory cytokines, especially tumour necrosis …

Inflammatory mediators and the failing heart: a translational approach

A Diwan, T Tran, A Misra… - Current molecular …, 2003 - ingentaconnect.com
Recent studies have identified the importance of proinflammatory mediators in regulating
cardiac structure in health and disease. Recent studies suggest that cytokines that are …

Inflammatory mediators and the failing heart: past, present, and the foreseeable future

DL Mann - Circulation research, 2002 - Am Heart Assoc
Recent studies have identified the importance of proinflammatory mediators in the
development and progression of heart failure. The growing appreciation of the …

Biology of TNFα and IL-10, and their imbalance in heart failure

K Kaur, S Dhingra, J Slezak, AK Sharma, A Bajaj… - Heart failure …, 2009 - Springer
Our understanding of the multiple in vivo functions of the proinflammatory cytokine, tumor
necrosis factor (TNFα), is advancing at a rapid pace. In addition to its antitumor effects …

Inflammatory biomarkers in heart failure

JW Petersen, GM Felker - Congestive heart failure, 2006 - Wiley Online Library
Multiple lines of evidence support the “cytokine hypothesis,” which suggests that
inflammation plays an important role in the development and progression of heart failure …

Cytokines in heart failure: pathogenetic mechanisms and potential treatment

Z Dibbs, K Kurrelmeyer, D Kalra, Y Seta… - Proceedings of the …, 1999 - Wiley Online Library
Recent studies have shown that patients with heart failure overexpress a class of
biologically active molecules, generically referred to as pro‐inflammatory cytokines. This …

Inflammation as a therapeutic target in heart failure? A scientific statement from the Translational Research Committee of the Heart Failure Association of the …

S Heymans, E Hirsch, SD Anker… - European journal of …, 2009 - Wiley Online Library
The increasing prevalence of heart failure poses enormous challenges for health care
systems worldwide. Despite effective medical interventions that target neurohumoral …

Immune modulation: role of the inflammatory cytokine cascade in the failing human heart

M Satoh, Y Minami, Y Takahashi… - Current heart failure reports, 2008 - Springer
Recent studies have determined that expression of inflammatory mediators, such as
cytokines and chemokines, is an important factor in the development and progression of …