Previous studies demonstrated that interleukin-10 (IL-10) overexpression decreases
formation of early fatty-streak lesions in mice independent of lipoprotein levels. The present …

The prevalence of atherosclerotic disease continues to increase, and despite significant
reductions in major cardiovascular events with current medical interventions, an additional …

Although it has been demonstrated that statins stabilize atherosclerotic lesions in animal
models of advanced atherosclerosis, there is little evidence to suggest that statins have a …

IκBNS is a nuclear IκB protein which negatively regulates nuclear factor-κB activity. We
demonstrated that IκBNS deficiency accelerates atherosclerosis in LDL receptor-deficient …

Objective—Vascular remodeling of the carotid artery with intima-media thickness (IMT) is an
important predictive factor for human cardiovascular disease. We characterized a mouse …

Background—The role of inflammation at all stages of the atherosclerotic process has
become an active area of investigation, and there is a notable quest for novel and innovative …

Background HDL cholesterol levels are inversely correlated with coronary heart disease risk
in humans, and in animal studies, HDL elevation decreases formation and progression of …

Objective—The development of a murine model of atherosclerotic plaque rupture. Methods
and Results—The left common carotid arteries of male apolipoprotein E (apoE)–deficient …

Epidemiological studies suggest that elevated plasma levels of plasminogen activator
inhibitor-1 (PAI-1) predispose an individual to ischemic heart disease or promote plaque …

Objective—Abdominal aortic aneurysms (AAAs) are common, but their exact pathogenesis
remains unknown and no specific medical therapies are available. We sought to evaluate …