Global changes in DNA methylation and hydroxymethylation in Alzheimer's disease human brain
N Coppieters, BV Dieriks, C Lill, RLM Faull… - Neurobiology of …, 2014 - Elsevier
Abstract DNA methylation (5-methylcytosine [5mC]) is one of several epigenetic markers
altered in Alzheimer's disease (AD) brain. More recently, attention has been given to DNA …
altered in Alzheimer's disease (AD) brain. More recently, attention has been given to DNA …
[HTML][HTML] Consistent decrease in global DNA methylation and hydroxymethylation in the hippocampus of Alzheimer's disease patients
L Chouliaras, D Mastroeni, E Delvaux, A Grover… - Neurobiology of …, 2013 - Elsevier
Epigenetic dysregulation of gene expression is thought to be critically involved in the
pathophysiology of Alzheimer's disease (AD). Recent studies indicate that DNA methylation …
pathophysiology of Alzheimer's disease (AD). Recent studies indicate that DNA methylation …
Dynamics of DNA methylation in aging and Alzheimer's disease
HA Irier, P Jin - DNA and cell biology, 2012 - liebertpub.com
Gene expression is modulated by epigenetic factors that come in varying forms, such as
DNA methylation, histone modifications, microRNAs, and long noncoding RNAs. Recent …
DNA methylation, histone modifications, microRNAs, and long noncoding RNAs. Recent …
Epigenetics in Alzheimer's disease: perspective of DNA methylation
Research over the years has shown that causes of Alzheimer's disease are not well
understood, but over the past years, the involvement of epigenetic mechanisms in the …
understood, but over the past years, the involvement of epigenetic mechanisms in the …
[HTML][HTML] From development to diseases: the role of 5hmC in brain
W Sun, L Zang, Q Shu, X Li - Genomics, 2014 - Elsevier
Epigenetic modulations play essential roles in diverse biological processes. During the past
several years, DNA demethylation has been discovered in embryonic and postnatal …
several years, DNA demethylation has been discovered in embryonic and postnatal …
Epigenetic changes in the progression of Alzheimer's disease
MA Bradley-Whitman, MA Lovell - Mechanisms of ageing and development, 2013 - Elsevier
Abstract The formation of 5-hydroxymethylcytosine (5hmC), a key intermediate of DNA
demethylation, is driven by the ten eleven translocation (TET) family of proteins that oxidize …
demethylation, is driven by the ten eleven translocation (TET) family of proteins that oxidize …
Dynamic regulation of DNA methylation and brain functions
J Xie, L Xie, H Wei, XJ Li, L Lin - Biology, 2023 - mdpi.com
Simple Summary DNA methylation is involved in biological processes including
neurogenesis, aging, and the pathogenesis of brain disorders by the regulation of gene …
neurogenesis, aging, and the pathogenesis of brain disorders by the regulation of gene …
Alterations in global DNA methylation and hydroxymethylation are not detected in A lzheimer's disease
Aims Genetic factors do not seem to account fully for A lzheimer disease (AD) pathogenesis.
There is evidence for the contribution of environmental factors, whose effect may be …
There is evidence for the contribution of environmental factors, whose effect may be …
The emerging role of 5-hydroxymethylcytosine in neurodegenerative diseases
S Al-Mahdawi, SA Virmouni, MA Pook - Frontiers in neuroscience, 2014 - frontiersin.org
DNA methylation primarily occurs within human cells as a 5-methylcytosine (5mC)
modification of the cytosine bases in CpG dinucleotides. 5mC has proven to be an important …
modification of the cytosine bases in CpG dinucleotides. 5mC has proven to be an important …
DNA methylation in Alzheimer's disease: In brain and peripheral blood
X Wei, L Zhang, Y Zeng - Mechanisms of Ageing and Development, 2020 - Elsevier
Alzheimer's disease (AD) is the most widespread neurodegenerative disorder and has
caused a major global health concern with the aging of the population. Recent studies have …
caused a major global health concern with the aging of the population. Recent studies have …
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