Introduction tricular arrhythmias are observed more often than in healthy animals (Hano et
al., 1991; Pogwizd, Ventricular arrhythmias are commonly observed in patients with …

Objective: After coronary artery occlusion, surviving myocardium in and around the infarct
zone plays an important role in arrhythmogenesis. Understanding the mechanisms for …

In acute myocardial ischemia slow conduction and short refractoriness both predispose to
cardiac arrhythmias. Moreover, spatial dispersion in these parameters, in part determined by …

Arrhythmias associated with reperfusion of is-chemic myocardium may be a major
progenitor for sudden cardiac death in man. The electrophysiological basis for arrhythmias …

Potassium is a major determinant of the electrophysiologic properties of the myocardial
membrane, and it plays an important role in the occurrence of arrhythmia. Hypokalemia has …

Using the isolated perfused rat heart with regional ischemia and reperfusion, we have two
antiarrhythmic interventions (the spin trap agent PBN [n-tert-butyl-alpha-phenylnitrone] and …

Down‐Regulation oi K+ Channel Genes and Currents. Introduction: Down‐regulaticn of key
K+ channel subunit gene expression and K+ currents is a universal response to cardiac …

Objective: The aim was to test the hypothesis that reperfusion induced arrhythmias are
associated with major alterations in intracellular calcium ([Ca2+] i) regulation. Methods …

We have confirmed the findings of Kantor and colleagues that ischemia-induced fibrillation
in isolated Langendorff-perfused rat hearts can be prevented by glyburide, a blocker of ATP …

The aim of the present study was to define the cellular mechanisms underlying changes in
K+ channel function in the failing heart after myocardial infarction. Rats with left coronary …