An investigation into the characteristics of reperfusion-induced arrhythmias in the anaesthetized rat and their susceptibility to antiarrhythmic agents.

KA Kane, JR Parratt, FM Williams - British journal of pharmacology, 1984 - ncbi.nlm.nih.gov
Reperfusion-induced arrhythmias were elicited in the pentobarbitone-anaesthetized rat by
occlusion of the left main coronary artery and subsequent release. These arrhythmias were …

Combined effects of hypoxia, hyperkalemia and acidosis on membrane action potential and excitability of guinea-pig ventricular muscle

I Kodama, A Wilde, MJ Janse, D Durrer… - Journal of molecular and …, 1984 - Elsevier
The effects of hypoxia (with and without acidosis) on membrane action potentials and
recovery kinetics of their upstroke velocity (V̇ max) were studied in isolated guinea-pig …

Reperfusion arrhythmias in isolated perfused pig hearts. Inhomogeneities in extracellular potassium, ST and TQ potentials, and transmembrane action potentials.

R Coronel, FJ Wilms-Schopman, T Opthof… - Circulation …, 1992 - Am Heart Assoc
We recorded direct current electrograms and local [K+] o at multiple sites and
transmembrane potentials at selected sites during reperfusion after 5 minutes and 10 …

Effects of glyburide on ischemia-induced changes in extracellular potassium and local myocardial activation: a potential new approach to the management of ischemia …

SS Bekheit, M Restivo, M Boutjdir, R Henkin… - American heart …, 1990 - Elsevier
The increase in extracellular potassium [K+] o levels during the early phase of myocardial
ischemia may result in part from activation of adenosine triphosphate-sensitive K+ channels …

Ventricular tachycardia in an isolated guinea pig ventricular free wall model of ischemia and reperfusion

GR Ferrier, CM Guyette - Journal of cardiovascular pharmacology, 1991 - journals.lww.com
Electrical activity from endo-and epicardium was recorded from isolated segments of right
ventricular free walls of guinea pigs using standard differential microelectrode techniques …

Interaction of hypokalemia and ventricular dilatation in isolated rabbit hearts

MJ Reiter, DE Mann… - American Journal of …, 1993 - journals.physiology.org
Potassium depletion has been implicated in the genesis of ventricular arrhythmias,
especially in patients with congestive heart failure, but the nature of this interaction is …

Two mechanisms of cardiac arrest produced by potassium

B SURAWICZ, LS GETTES, JC SHIVE… - Circulation …, 1963 - Am Heart Assoc
Ventricular arrest occurs in isolated heart perfused with potassium-deficient solution when
the extracellular potassium concentration is suddenly raised to a physiological …

Models for the study of arrhythmias in myocardial ischaemia and infarction: the use of the rat

MJ Curtis, BA Macleod, MJA Walker - Journal of molecular and cellular …, 1987 - Elsevier
Models for the study of arrhythmias in myocardial ischaemia and infarction: the use of the rat -
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Acute coronary artery occlusion-reperfusion-induced arrhythmias in rats, dogs and pigs: antiarrhythmic evaluation of quinidine, procainamide and lidocaine

JL Bergey, K Nocella, JD McCallum - European Journal of Pharmacology, 1982 - Elsevier
Arrhythmias which occur following either abrupt occlusion (CO) of the left anterior
descending coronary artery (LAD), or rapid reperfusion (CR) of the same, were studied in …

Density and Kinetics of IKr and IKs in Guinea Pig and Rabbit Ventricular Myocytes Explain Different Efficacy of IKs Blockade at High Heart Rate in Guinea Pig and …

Z Lu, K Kamiya, T Opthof, K Yasui, I Kodama - Circulation, 2001 - Am Heart Assoc
Background—Class III antiarrhythmic agents commonly exhibit reverse frequency-
dependent prolongation of the action potential duration (APD). This is undesirable because …