An update on cell-penetrating peptides with intracellular organelle targeting

CP Cerrato, Ü Langel - Expert Opinion on Drug Delivery, 2022 - Taylor & Francis
Introduction Cell-penetrating peptide (CPP) technologies represent an important strategy to
address drug delivery to specific intracellular compartments by covalent conjugation to …

Recent developments in anticancer drug delivery using cell penetrating and tumor targeting peptides

S Dissanayake, WA Denny, S Gamage… - Journal of Controlled …, 2017 - Elsevier
Efficient intracellular trafficking and targeted delivery to the site of action are essential to
overcome the current drawbacks of cancer therapeutics. Cell Penetrating Peptides (CPPs) …

Cell-penetrating peptides: Applications in tumor diagnosis and therapeutics

J Stiltner, K McCandless, M Zahid - Pharmaceutics, 2021 - mdpi.com
Since their identification over twenty-five years ago, the plethora of cell-penetrating peptides
(CPP) and their applications has skyrocketed. These 5 to 30 amino acid in length peptides …

The role of cell‐penetrating peptides in potential anti‐cancer therapy

M Zhou, X Zou, K Cheng, S Zhong, Y Su… - Clinical and …, 2022 - Wiley Online Library
Due to the complex physiological structure, microenvironment and multiple physiological
barriers, traditional anti‐cancer drugs are severely restricted from reaching the tumour site …

Cell penetrating peptides: efficient vectors for delivery of nanoparticles, nanocarriers, therapeutic and diagnostic molecules

SM Farkhani, A Valizadeh, H Karami, S Mohammadi… - Peptides, 2014 - Elsevier
Efficient delivery of therapeutic and diagnostic molecules to the cells and tissues is a difficult
challenge. The cellular membrane is very effective in its role as a selectively permeable …

Recent CPP-based applications in medicine

K Kurrikoff, Ü Langel - Expert opinion on drug delivery, 2019 - Taylor & Francis
Introduction: Cell-penetrating peptides (CPP) offer versatile tools for the field of drug delivery
and development of macromolecular therapeutics. These tools have matured into …

Cell-penetrating peptides: design, synthesis, and applications

DM Copolovici, K Langel, E Eriste, U Langel - ACS nano, 2014 - ACS Publications
The intrinsic property of cell-penetrating peptides (CPPs) to deliver therapeutic molecules
(nucleic acids, drugs, imaging agents) to cells and tissues in a nontoxic manner has …

Applications of cell-penetrating peptides for tumor targeting and future cancer therapies

J Regberg, A Srimanee, Ü Langel - Pharmaceuticals, 2012 - mdpi.com
Cell-penetrating peptides provide a highly promising strategy for intracellular drug delivery.
One relevant clinical application of cell-penetrating peptides is cancer therapeutics. Peptide …

[HTML][HTML] Cell penetrating peptides in preclinical and clinical cancer diagnosis and therapy

PP Tripathi, H Arami, I Banga, J Gupta, S Gandhi - Oncotarget, 2018 - ncbi.nlm.nih.gov
Delivery of imaging reagents and drugs to tumors is essential for cancer diagnosis and
therapy. In addition to therapeutic and diagnostic functionalities, peptides have potential …

Cell-penetrating peptides with intracellular organelle targeting

CP Cerrato, K Künnapuu, Ü Langel - Expert opinion on drug …, 2017 - Taylor & Francis
Introduction: One of the major limiting steps in order to have an effective drug is the passage
through one or more cell membranes to reach its site of action. To reach the action-site, the …