Based on their tunable physicochemical properties and the possibility of producing cell-
specific platforms through surface modification with functional biomolecules, nanoparticles …

The penetration of polar or badly soluble compounds through a cell membrane into live cells
requires mechanical support or chemical helpers. Cell‐penetrating peptides (CPPs) are very …

Protein therapy exhibits several advantages over small molecule drugs and is increasingly
being developed for the treatment of disorders ranging from single enzyme deficiencies to …

The selective permeability of the plasma membrane prohibits most exogenous agents from
gaining cellular access. Since many therapeutics and reporter molecules must be …

Biophysical studies have a very high impact on the understanding of internalization,
molecular mechanisms, interactions, and localization of CPPs and CPP/cargo conjugates in …

Drug conjugates have become a significant focus of research in the field of targeted
medicine for cancer treatments. Peptide-drug conjugates (PDCs), a subset of drug …

Cell-penetrating compounds are substances that enhance the cellular uptake of various
molecular cargoes that do not easily cross the cellular membrane. The majority of cell …

Most toxic agents currently used for chemotherapy show a narrow therapeutic window,
because of their inability to distinguish between healthy and cancer cells. Targeted drug …

Cancer remains the leading cause of death worldwide despite advances in treatment
options for patients. As such, safe and effective therapeutics are required. Short peptides …

Cell-penetrating peptides have gained attention owing to their promise in noninvasive
delivery systems. Among the identified cell-penetrating peptides, the TAT peptide has been …