Cell penetrating peptides: classification, mechanisms, methods of study, and applications

A Gori, G Lodigiani, SG Colombarolli… - …, 2023 - Wiley Online Library
Cell‐penetrating peptides (CPPs) encompass a class of peptides that possess the
remarkable ability to cross cell membranes and deliver various types of cargoes, including …

[HTML][HTML] Cell-penetrating peptides in diagnosis and treatment of human diseases: from preclinical research to clinical application

J Xie, Y Bi, H Zhang, S Dong, L Teng, RJ Lee… - Frontiers in …, 2020 - frontiersin.org
Cell-penetrating peptides (CPPs) are short peptides (fewer than 30 amino acids) that have
been predominantly used in basic and preclinical research during the last 30 years. Since …

[HTML][HTML] Peptides as multifunctional players in cancer therapy

SMP Vadevoo, S Gurung, HS Lee… - … & Molecular Medicine, 2023 - nature.com
Peptides exhibit lower affinity and a shorter half-life in the body than antibodies. Conversely,
peptides demonstrate higher efficiency in tissue penetration and cell internalization than …

Peptides for cell-selective drug delivery

N Svensen, JGA Walton, M Bradley - Trends in pharmacological sciences, 2012 - cell.com
The ability to target specific cell types to achieve optimal distribution of therapeutic entities
into diseased tissues, while limiting possible adverse off-target effects, has long been a goal …

Cell targeting peptides as smart ligands for targeting of therapeutic or diagnostic agents: a systematic review

A Mousavizadeh, A Jabbari, M Akrami… - Colloids and Surfaces B …, 2017 - Elsevier
Cell targeting peptides (CTP) are small peptides which have high affinity and specificity to a
cell or tissue targets. They are typically identified by using phage display and chemical …

On the biomedical promise of cell penetrating peptides: limits versus prospects

C Foerg, HP Merkle - Journal of pharmaceutical sciences, 2008 - Elsevier
The cell membrane poses a substantial hurdle to the use of pharmacologically active
biomacromolecules that are not per se actively translocated into cells. An appealing …

Mechanism matters: a taxonomy of cell penetrating peptides

WB Kauffman, T Fuselier, J He, WC Wimley - Trends in biochemical …, 2015 - cell.com
The permeability barrier imposed by cellular membranes limits the access of exogenous
compounds to the interior of cells. Researchers and patients alike would benefit from …

Tumor‐homing peptide and its utility for advanced cancer medicine

E Kondo, H Iioka, K Saito - Cancer Science, 2021 - Wiley Online Library
Cell‐penetrating peptides, such as antibodies, have gained great attention as tools for the
development of specific delivery systems for payloads, which might be applied as non …

Cell‐penetrating peptides: Nanocarrier for macromolecule delivery in living cells

A Chugh, F Eudes, YS Shim - IUBMB life, 2010 - Wiley Online Library
Novel classes and applications of cell‐penetrating peptides (CPPs) are being constantly
discovered since they were first identified 2 decades ago. These short cationic peptides …

[HTML][HTML] Intracellular delivery of molecular cargo using cell-penetrating peptides and the combination strategies

H Li, TY Tsui, W Ma - International journal of molecular sciences, 2015 - mdpi.com
Cell-penetrating peptides (CPPs) can cross cellular membranes in a non-toxic fashion,
improving the intracellular delivery of various molecular cargos such as nanoparticles, small …