Neuronal nitric oxide synthase (nNOS or NOS1) is the major endogenous source of
myocardial nitric oxide (NO), which facilitates cardiac relaxation and modulates contraction …

Nitric oxide (NO) is an imperative regulator of the cardiovascular system and is a critical
mechanism in preventing the pathogenesis and progression of the diseased heart. The …

Hypertension is a prevalent condition worldwide and is the key risk factor for fatal
cardiovascular complications, such as stroke, sudden cardiac death and heart failure …

Emerging evidence shows that neuronal nitric oxide synthase (nNOS) plays several
diverging roles in modulating cardiac function. This review examines the nitric oxide (NO) …

Nitric oxide is a key signaling molecule in the heart and is produced endogenously by three
isoforms of nitric oxide synthase, neuronal NOS (NOS1), endothelial NOS (NOS3), and …

The recent discovery of a NOS1 gene product (ie a neuronal‐like isoform of nitric oxide
synthase or nNOS) in the mammalian left ventricular (LV) myocardium has provided a new …

Angiotensin II (Ang II) is critical in myocardial pathogenesis, mostly via stimulating NADPH
oxidase. Neuronal nitric oxide synthase (nNOS) has recently been shown to play important …

Significant advances in our understanding of the ability of nitric oxide synthases (NOS) to
modulate cardiac function have provided key insights into the role NOS play in the …

Constitutive nitric oxide synthases (NOSs) are ubiquitous enzymes that play a pivotal role in
the regulation of myocardial function in health and disease. The discovery of both a …

Nitric oxide (NO) has been shown to regulate cardiac function, both in physiological
conditions and in disease states. However, several aspects of NO signalling in the …