Halogenated 4-hydroxybenzylidene indolinones have been shown to re-sensitize methicillin-
resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecalis …

For many years, we have tried to use antibiotics to eliminate the persistence of pathogenic
bacteria. However, these infectious agents can recover from antibiotic challenges through …

Efflux pumps are always at the forefront of bacterial multidrug resistance and account for the
failure of antibiotics. The present study explored the potential of 2-(2-Aminophenyl) indole …

Antibiotics disturb the physiological homeostasis of bacterial cells by interfering with
essential cellular functions or structures. The bacterial proteome adjusts quickly in response …

Emodin has a strong antibacterial activity, including methicillin-resistant Staphylococcus
aureus (MRSA). However, the mechanism by which emodin induces growth inhibition …

Berberine is an isoquinoline alkaloid found in many plants. Although berberine is known to
possess the antibacterial activity against Streptococcus pyogenes, the mechanism …

Staphylococcus aureus (S. aureus) is a common pathogen that causes various serious
diseases, including chronic infections. Discovering new antibacterial agents is an important …

Antibiotic resistance/tolerance has become a severe threat to human and animal health. To
combat antibiotic-resistant/tolerant bacteria, it is of significance to improve the efficacy of …

The past few decades have been plagued by an increasing number of infections caused by
antibiotic resistant bacteria. To mitigate the rise in untreatable infections, we need new …

The increasing emergence of antibiotic resistance is an urgent threat to global health care;
thus, there is a need for new therapeutics. Guanidine is the preferred functional group for …