The past few decades have been plagued by an increasing number of infections caused by
antibiotic resistant bacteria. To mitigate the rise in untreatable infections, we need new …

Antibiotic resistance/tolerance has become a severe threat to human and animal health. To
combat antibiotic-resistant/tolerant bacteria, it is of significance to improve the efficacy of …

The increasing emergence of antibiotic resistance is an urgent threat to global health care;
thus, there is a need for new therapeutics. Guanidine is the preferred functional group for …

Anti-virulence agents are non-bacteriostatic and non-bactericidal emerging therapeutic
options which hamper the production of virulence factors in pathogenic flora. In …

The use of antibacterial drug combinations with synergistic effects is increasingly seen as a
critical strategy to combat multi-drug resistant bacteria such as methicillin-resistant …

Infections caused by multidrug-resistant bacteria are becoming increasingly serious. The
aminoglycoside antibiotics have been widely used to treat severe Gram-negative bacterial …

Staphylococcus aureus, including MRSA strains, poses significant health risks, imposing a
significant disease burden and mortality. We investigate butyrolactone I (BL-1), a marine …

Despite the ever-growing antibiotic resistance crisis, the rate at which new antimicrobials are
being discovered and approved for human use has rapidly declined over the past 75 years …

Antibiotic screens typically rely on growth inhibition to characterize compound bioactivity—
an approach that cannot be used to assess the bactericidal activity of antibiotics against …

The alarming global rise in fatalities from multidrug-resistant Staphylococcus aureus (S.
aureus) infections has underscored a need to develop new therapies to address this …