Escaping ESKAPE resistance: in vitro and in silico studies of multifunctional carbamimidoyl-tethered indoles against antibiotic-resistant bacteria
K Gulia, AHE Hassan, JR Lenhard… - Royal Society Open …, 2023 - royalsocietypublishing.org
Combining the hybridization and repurposing strategies, six compounds from our in-house
library and having a designed hybrid structure of MBX-1162, pentamidine and MMV688271 …
library and having a designed hybrid structure of MBX-1162, pentamidine and MMV688271 …
Multi-armed antibiotics for Gram-positive bacteria
Antibiotic resistance is a serious threat to public health. Here, we propose a multi-armed
chemical scaffold (MACS) for antibiotic screening, which refers to multi-armed molecules …
chemical scaffold (MACS) for antibiotic screening, which refers to multi-armed molecules …
Call for next-generation drugs that remove the uptake barrier to combat antibiotic resistance
B Peng, H Li, X Peng - Drug Discovery Today, 2023 - Elsevier
Existing antibacterial agents can be categorized into two generations, but bacterial
insensitivity towards both of these classes poses a serious public health challenge …
insensitivity towards both of these classes poses a serious public health challenge …
Development of a luciferase-based Gram-positive bacterial reporter system for the characterization of antimicrobial agents
NM Lam, TF Tsang, J Qu, MW Tsang… - Applied and …, 2024 - journals.asm.org
Mechanistic investigations are of paramount importance in elucidating the modes of action
of antibiotics and facilitating the discovery of novel drugs. We reported a luciferase-based …
of antibiotics and facilitating the discovery of novel drugs. We reported a luciferase-based …
Rapid Inhibition Profiling in Bacillus subtilis to Identify the Mechanism of Action of New Antimicrobials
A Lamsa, J Lopez-Garrido, D Quach… - ACS chemical …, 2016 - ACS Publications
Increasing antimicrobial resistance has become a major public health crisis. New
antimicrobials with novel mechanisms of action (MOA) are desperately needed. We …
antimicrobials with novel mechanisms of action (MOA) are desperately needed. We …
A screen for and validation of prodrug antimicrobials
LE Fleck, EJ North, RE Lee, LR Mulcahy… - Antimicrobial agents …, 2014 - Am Soc Microbiol
The rise of resistant pathogens and chronic infections tolerant to antibiotics presents an
unmet need for novel antimicrobial compounds. Identifying broad-spectrum leads is …
unmet need for novel antimicrobial compounds. Identifying broad-spectrum leads is …
Effect of Three Different Amino Acids Plus Gentamicin Against Methicillin-Resistant Staphylococcus aureus
J Guo, Z Pan, L Fan, Y Zhong, R Pang… - Infection and Drug …, 2023 - Taylor & Francis
Background The issue of methicillin-resistant Staphylococcus aureus (MRSA) resistant to
many antibiotics and causing serious infectious diseases is a growing healthcare concern …
many antibiotics and causing serious infectious diseases is a growing healthcare concern …
Proteomic interrogation of antibiotic resistance and persistence in Escherichia coli – progress and potential for medical research
D Zhang, Y Hu, Q Zhu, J Huang… - Expert Review of …, 2020 - Taylor & Francis
Introduction Escherichia coli strains possess two survival strategies to endure lethal
antibiotic exposure including antibiotic resistance and persistence, in which persistence can …
antibiotic exposure including antibiotic resistance and persistence, in which persistence can …
[HTML][HTML] Antimicrobial compounds from microorganisms
C Amaning Danquah, PAB Minkah, I Osei Duah Junior… - Antibiotics, 2022 - mdpi.com
Antimicrobial resistance is an exigent public health concern owing to the emergence of
novel strains of human resistant pathogens and the concurrent rise in multi-drug resistance …
novel strains of human resistant pathogens and the concurrent rise in multi-drug resistance …
Facilitating compound entry as a means to discover antibiotics for gram-negative bacteria
KA Muñoz, PJ Hergenrother - Accounts of chemical research, 2021 - ACS Publications
Conspectus It has been over half a century since the last class of antibiotics active against
the most problematic Gram-negative bacteria was approved by the Food and Drug …
the most problematic Gram-negative bacteria was approved by the Food and Drug …