Combining the hybridization and repurposing strategies, six compounds from our in-house
library and having a designed hybrid structure of MBX-1162, pentamidine and MMV688271 …

Antibiotic resistance is a serious threat to public health. Here, we propose a multi-armed
chemical scaffold (MACS) for antibiotic screening, which refers to multi-armed molecules …

Existing antibacterial agents can be categorized into two generations, but bacterial
insensitivity towards both of these classes poses a serious public health challenge …

Mechanistic investigations are of paramount importance in elucidating the modes of action
of antibiotics and facilitating the discovery of novel drugs. We reported a luciferase-based …

Increasing antimicrobial resistance has become a major public health crisis. New
antimicrobials with novel mechanisms of action (MOA) are desperately needed. We …

The rise of resistant pathogens and chronic infections tolerant to antibiotics presents an
unmet need for novel antimicrobial compounds. Identifying broad-spectrum leads is …

Background The issue of methicillin-resistant Staphylococcus aureus (MRSA) resistant to
many antibiotics and causing serious infectious diseases is a growing healthcare concern …

Introduction Escherichia coli strains possess two survival strategies to endure lethal
antibiotic exposure including antibiotic resistance and persistence, in which persistence can …

Antimicrobial resistance is an exigent public health concern owing to the emergence of
novel strains of human resistant pathogens and the concurrent rise in multi-drug resistance …

Conspectus It has been over half a century since the last class of antibiotics active against
the most problematic Gram-negative bacteria was approved by the Food and Drug …