IL-17A and IL-17F do not contribute vitally to autoimmune neuro-inflammation in mice
S Haak, AL Croxford, K Kreymborg… - The Journal of …, 2009 - Am Soc Clin Investig
The clear association of Th17 cells with autoimmune pathogenicity implicates Th17
cytokines as critical mediators of chronic autoimmune diseases such as EAE. To study the …
cytokines as critical mediators of chronic autoimmune diseases such as EAE. To study the …
Interleukin-17A serves a priming role in autoimmunity by recruiting IL-1β-producing myeloid cells that promote pathogenic T cells
Summary Interleukin-17A (IL-17A) is a major mediator of tissue inflammation in many
autoimmune diseases. Anti-IL-17A is an effective treatment for psoriasis and is showing …
autoimmune diseases. Anti-IL-17A is an effective treatment for psoriasis and is showing …
IL-17RC is required for IL-17A–and IL-17F–dependent signaling and the pathogenesis of experimental autoimmune encephalomyelitis
It has been suggested that IL-17RC forms a complex with IL-17RA to mediate the functions
of IL-17A and IL-17F homodimers as well as IL-17A/F heterodimers. It is still unclear whether …
of IL-17A and IL-17F homodimers as well as IL-17A/F heterodimers. It is still unclear whether …
Autoimmune inflammation from the Th17 perspective
J Furuzawa-Carballeda, MI Vargas-Rojas… - Autoimmunity reviews, 2007 - Elsevier
Recent studies demonstrated an IL-17-producer CD4+ T cell subpopulation, termed Th17,
distinct from Th1 and Th2. It represents a different pro-inflammatory Th-cell lineage. This …
distinct from Th1 and Th2. It represents a different pro-inflammatory Th-cell lineage. This …
IL-22 is expressed by Th17 cells in an IL-23-dependent fashion, but not required for the development of autoimmune encephalomyelitis
K Kreymborg, R Etzensperger, L Dumoutier… - The Journal of …, 2007 - journals.aai.org
Abstract Lately, IL-17-secreting Th cells have received an overwhelming amount of attention
and are now widely held to be the major pathogenic population in autoimmune diseases. In …
and are now widely held to be the major pathogenic population in autoimmune diseases. In …
TH17 cytokines in autoimmune neuro-inflammation
B Becher, BM Segal - Current opinion in immunology, 2011 - Elsevier
It has been firmly established that IL-23 polarized TH17 cells are potent effectors in the
pathogenesis of experimental autoimmune encephalitomyelitis (EAE). However, the relative …
pathogenesis of experimental autoimmune encephalitomyelitis (EAE). However, the relative …
Induction of experimental autoimmune encephalomyelitis in IL-12 receptor-β2-deficient mice: IL-12 responsiveness is not required in the pathogenesis of inflammatory …
GX Zhang, B Gran, S Yu, J Li, I Siglienti… - The Journal of …, 2003 - journals.aai.org
IL-12 is thought to be involved in the susceptibility to experimental autoimmune
encephalomyelitis (EAE), a Th1 cell-mediated autoimmune disorder of the CNS. IL-12 …
encephalomyelitis (EAE), a Th1 cell-mediated autoimmune disorder of the CNS. IL-12 …
Th17 cells, γδ T cells and their interplay in EAE and multiple sclerosis
AM McGinley, SC Edwards, M Raverdeau… - Journal of …, 2018 - Elsevier
Experimental autoimmune encephalomyelitis (EAE) is an animal model of multiple sclerosis
(MS) that shares many features with the human disease. This review will focus on the role of …
(MS) that shares many features with the human disease. This review will focus on the role of …
IL-17A secretion by CD8+ T cells supports Th17-mediated autoimmune encephalomyelitis
M Huber, S Heink, A Pagenstecher… - The Journal of …, 2012 - Am Soc Clin Investig
IL-17–producing CD8+ T (Tc17) cells are detectible in multiple sclerosis (MS) lesions;
however, their contribution to the disease is unknown. To identify functions of Tc17 cells, we …
however, their contribution to the disease is unknown. To identify functions of Tc17 cells, we …
Interleukin-1 and IL-23 induce innate IL-17 production from γδ T cells, amplifying Th17 responses and autoimmunity
CE Sutton, SJ Lalor, CM Sweeney, CF Brereton… - Immunity, 2009 - cell.com
Summary Th17 cells, CD4+ T cells that secrete interleukin-17 (IL-17), are pathogenic in
autoimmune diseases and their development and expansion is driven by the cytokines IL-6 …
autoimmune diseases and their development and expansion is driven by the cytokines IL-6 …