Hypoxia, a prevalent characteristic of most solid malignant tumors, contributes to diminished
therapeutic responses and more aggressive phenotypes. The term hypoxia has two …

PURPOSE: Tumor hypoxia plays a fundamental role in tumor progression and treatment
resistance. Recent evidence that hypoxia also influences the regulation and transcription of …

The presence of radiation resistant cells in solid human tumors is believed to be a major
reason why radiotherapy fails to eradicate some such neoplasms. The presence of …

Tumors exhibit areas of decreased oxygenation due to malformed blood vessels. This low
oxygen concentration decreases the effectiveness of radiation therapy, and the resulting …

Purpose: The Cancer Imaging Program of the National Cancer Institute convened a
workshop to assess the current status of hypoxia imaging, to assess what is known about the …

Tumor hypoxia or a reduction of the tissue oxygen tension is a key microenvironmental
factor for tumor progression and treatment resistance in solid tumors. Because hypoxic …

Hypoxia is a hallmark of tumors leading to (mal-) adaptive processes, development of
aggressive phenotypes and treatment resistance. Based on underlying mechanisms and …

Tissue hypoxia results from an inadequate supply of oxygen (O2) that compromises biologic
functions. Evidence from experimental and clinical studies increasingly points to a …

Hypoxia is present to some extent in most solid malignant human cancers because of an
imbalance between the limited oxygen delivery capacity of the abnormal vasculature and …

Tumor hypoxia and its downstream effects have remained of considerable interest for
decades due to its negative impact on response to various cancer therapies and promotion …