Mammalian reproductive function is a complex system of many players orchestrated by the
hypothalamus-pituitary–gonadal (HPG) axis. The hypothalamic gonadotropin-releasing …

Kisspeptin plays a pivotal role in pubertal onset and reproductive function. In rodents,
kisspeptin perikarya are located in 2 major populations: the anteroventral periventricular …

Estrogen produced by ovarian follicles plays a key role in the central mechanisms
controlling reproduction via regulation of gonadotropin-releasing hormone (GnRH) release …

Ovulation is an essential phenomenon for reproduction in mammalian females along with
follicular growth. It is well established that gonadal function is controlled by the …

Kisspeptin plays a critical role in pubertal timing and reproductive function. In rodents,
kisspeptin perikarya within the hypothalamic arcuate (ARC) and anteroventral …

The brain mechanism regulating gonadotropin-releasing hormone (GnRH)/luteinizing
hormone (LH) release is sexually differentiated in rodents. Kisspeptin neurons in the …

In humans, as in the other mammals, the neuroendocrine control of reproduction is ensured
by the brain-pituitary gonadotropic axis. Multiple internal and environmental cues are …

Ovarian steroids, estradiol and progesterone, play central roles in regulating female
reproduction by acting as both positive and negative regulators of gonadotropin-releasing …

Kisspeptin is a neuropeptide with a critical role in the function of the hypothalamic–pituitary–
gonadal (HPG) axis. Kisspeptin is produced by two major populations of neurons located in …

Hypothalamic control of fertility is the quintessential homeostatic function. However, fertility is
metabolically demanding; so, there must be coordination between energy states and …