The benefit of individualized vancomycin dosing via pharmacokinetic tools: a systematic review and meta-analysis

N He, S Su, Y Yan, W Liu… - Annals of …, 2020 - journals.sagepub.com
Background: Various pharmacokinetic (PK) equations and software have been developed to
individualize vancomycin dosing. However, the benefit of using any PK information to guide …

Individualized vancomycin dosing with therapeutic drug monitoring and pharmacokinetic consultation service: a large-scale retrospective observational study

SM Kim, HS Lee, NY Hwang, K Kim… - Drug Design …, 2021 - Taylor & Francis
Background To date, outcome data with a large sample size and data regarding the clinical
outcomes of pharmacokinetic-guided (PK) dosing of vancomycin are limited. Aim We …

[HTML][HTML] The monitoring of vancomycin: a systematic review and meta-analyses of area under the concentration-time curve-guided dosing and trough-guided dosing

M Tsutsuura, H Moriyama, N Kojima, Y Mizukami… - BMC infectious …, 2021 - Springer
Background This systematic review and meta-analysis explored the relationship between
vancomycin (VCM) monitoring strategies and VCM effectiveness and safety. Methods We …

[HTML][HTML] Evaluation of traditional initial vancomycin dosing versus utilizing an electronic AUC/MIC dosing program

KA Mcgrady, M Benton, S Tart… - Pharmacy Practice …, 2020 - SciELO Espana
Resumen MCGRADY, Kerri A; BENTON, Makenzie; TART, Serina y BOWERS, Riley.
Evaluation of traditional initial vancomycin dosing versus utilizing an electronic AUC/MIC …

[HTML][HTML] Two innovative approaches to optimize vancomycin dosing using estimated AUC after first dose: validation using data generated from population PK model …

Q Liu, H Huang, B Xu, D Li, M Liu, IH Shaik, X Wu - Pharmaceutics, 2022 - mdpi.com
The revised consensus guidelines for optimizing vancomycin doses suggest that
maintaining the area under the concentration-time curve to minimal inhibitory concentration …

Sustained improvement in vancomycin dosing and monitoring post-implementation of guidelines: results of a three-year follow-up after a multifaceted intervention in …

CJ Phillips, RA McKinnon, RJ Woodman… - Journal of Infection and …, 2018 - Elsevier
Introduction Despite vancomycin being in use for over half-a-century, it is still not dosed or
monitored appropriately in many centers around the world. The objective of this study was to …

Vancomycin dosing: assessment of time to therapeutic concentration and predictive accuracy of pharmacokinetic modeling software

MO Nunn, CE Corallo, C Aubron… - Annals of …, 2011 - journals.sagepub.com
BACKGROUND: Therapeutic drug monitoring is usually required for safe and effective
administration of vancomycin. However, dosing recommendations from published …

[HTML][HTML] The clinical efficacy and safety of vancomycin loading dose: A systematic review and meta-analysis

H Mei, J Wang, H Che, R Wang, Y Cai - Medicine, 2019 - journals.lww.com
Background: The clinical significance of using vancomycin loading dose remains
controversial. A systematic review and meta-analysis were performed to assess the clinical …

[HTML][HTML] Vancomycin pharmacokinetics throughout life: results from a pooled population analysis and evaluation of current dosing recommendations

PJ Colin, K Allegaert, AH Thomson, DJ Touw… - Clinical …, 2019 - Springer
Abstract Background and Objectives Uncertainty exists regarding the optimal dosing
regimen for vancomycin in different patient populations, leading to a plethora of subgroup …

An update on population pharmacokinetic analyses of vancomycin, part I: in adults

A Aljutayli, A Marsot, F Nekka - Clinical pharmacokinetics, 2020 - Springer
Despite the wide clinical use of vancomycin, controversy remains regarding its optimal
dosage regimens. This can be attributed to the large between-and within-subject variability …