In recent years, diabetes and its associated complications have come to represent a major
public health concern. It is a complex disease characterized by multiple metabolic …

Diabetes diagnoses are increasing at an alarming rate worldwide. The majority of diabetes-
related deaths arise from cardiovascular complications such as myocardial infarction, stroke …

Cardiovascular complications, characterized by endothelial dysfunction and accelerated
atherosclerosis, are the leading cause of morbidity and mortality associated with diabetes …

Type 2 diabetes is a worldwide increasing disease resulting from the interaction between a
subject's genetic makeup and lifestyle. In genetically predisposed subjects, the combination …

Twenty years have passed since Brownlee and colleagues proposed a single unifying
mechanism for diabetic complications, introducing a turning point in this field of research …

Increasing evidence in both experimental and clinical studies suggests that oxidative stress
plays a major role in the pathogenesis of both types of diabetes mellitus. Free radicals are …

This volume summarizes current understanding of the pathogenic role of oxidative stress in
the onset and progression of diabetes and its complications, and presents results of studies …

Obesity, metabolic syndrome, and diabetes are increasingly prevalent in Western society,
and they markedly increase the risk for atherosclerotic vascular disease, the major cause of …

Many therapeutic agents that are used in patients with diabetes mitigate oxidative stress.
These agents are of particular interest because oxidative stress is elevated in diabetes and …

Introduction 3. Pathophysiology of diabetic complications 3.1. Hyperglycemia and diabetic
complications 3.2. Mechanisms of tissue damage mediated by hyperglycemia 4. Oxidative …