Differential growth factor control of bone formation through osteoprogenitor differentiation

LR Chaudhary, AM Hofmeister, KA Hruska - Bone, 2004 - Elsevier
The osteogenic factors bone morphogenetic protein (BMP-7), platelet-derived growth factor
(PDGF)-BB, and fibroblast growth factor (FGF-2) regulate the recruitment of osteoprogenitor …

Effects of heterodimeric bone morphogenetic protein‐2/7 on osteogenesis of human adipose‐derived stem cells

X Zhang, J Guo, G Wu, Y Zhou - Cell Proliferation, 2015 - Wiley Online Library
Objective Roles of bone morphogenetic proteins (BMP s) on osteogenesis of human
adipose‐derived stem cells (hASC s) remain ambiguous. In this study, we evaluated in vitro …

Growth factor gene expression profiles of bone morphogenetic protein-2-treated human adipose stem cells seeded on calcium phosphate scaffolds in vitro

JR Overman, MN Helder, CM ten Bruggenkate… - Biochimie, 2013 - Elsevier
The secretome of stem cells strongly determines the outcome of tissue engineering
strategies. We investigated how the secretome of human adipose stem cells (hASCs) can be …

The effects of BMP6 overexpression on adipose stem cell chondrogenesis: Interactions with dexamethasone and exogenous growth factors

BO Diekman, BT Estes, F Guilak - … Part A: An Official Journal of …, 2010 - Wiley Online Library
Adipose‐derived stem cells (ASCs) are multipotent progenitors that can be chondrogenically
induced by growth factors such as bone morphogenetic protein 6 (BMP‐6). We …

Co-stimulation with bone morphogenetic protein-9 and FK506 induces remarkable osteoblastic differentiation in rat dedifferentiated fat cells

T Nakamura, Y Shinohara, S Momozaki… - Biochemical and …, 2013 - Elsevier
Dedifferentiated fat (DFAT) cells, which are isolated from mature adipocytes using the ceiling
culture method, exhibit similar characteristics to mesenchymal stem cells, and possess …

Combination of Transforming Growth Factor-Beta2 and Bone Morphogenetic Protein 7 Enhances Chondrogenesis from Adipose Tissue-Derived Mesenchymal Stem …

HJ Kim, GI Im - Tissue Engineering Part A, 2009 - liebertpub.com
In this study, the authors examined combinations of growth factors that induce effective
chondrogenesis from adipose tissue–derived mesenchymal stem cells (MSCs). Human …

Platelet-derived growth factor BB enhances osteogenesis of adipose-derived but not bone marrow-derived mesenchymal stromal/stem cells

BP Hung, DL Hutton, KL Kozielski, CJ Bishop… - Stem Cells, 2015 - academic.oup.com
Tissue engineering using mesenchymal stem cells (MSCs) holds great promise for
regenerating critically sized bone defects. While the bone marrow-derived MSC is the most …

Disruption of the Fgf2 gene activates the adipogenic and suppresses the osteogenic program in mesenchymal marrow stromal stem cells

L Xiao, T Sobue, A Esliger, MS Kronenberg, JD Coffin… - Bone, 2010 - Elsevier
Here we determine the Fibroblast Growth Factor-2 (FGF2) dependency of the time course of
changes in bone mass in female mice. This study extends our earlier reports that knockout of …

Gdf6 induces commitment of pluripotent mesenchymal C3H10T1/2 cells to the adipocyte lineage

SS Wang, HY Huang, SZ Chen, X Li… - The FEBS …, 2013 - Wiley Online Library
Mesenchymal stem cells have the potential to undergo commitment and differentiation into a
variety of cell types, including osteoblasts, chondrocytes, myocytes and adipocytes. Growth …

The effect of growth/differentiation factor-5 deficiency on femoral composition and mechanical behavior in mice

B Mikic, TC Battaglia, EA Taylor, RT Clark - Bone, 2002 - Elsevier
A subclass of the bone morphogenetic proteins (BMPs), known as growth/differentiation
factors (GDFs) 5, 6, and 7, have been shown to affect several skeletal processes, including …