HIV prevention in developed countries is marked by impressive successes and dismal
failures. The successes point the way to what works; the failures highlight obstacles that …

The HIV-1 pandemic is a complex mix of diverse epidemics within and between countries
and regions of the world, and is undoubtedly the defining public-health crisis of our time …

Background New WHO guidelines recommend initiation of antiretroviral therapy for HIV-
positive adults with CD4 counts of 500 cells per μL or less, a higher threshold than was …

With more than 1· 2 million people living with HIV in the USA, a complex epidemic across the
large and diverse country, and a fragmented health-care system marked by widening health …

In 2006, WHO set forth its vision for a public health approach to delivering antiretroviral
therapy. This approach has been broadly adopted in resource-poor settings and has …

Background The cascade of HIV care has become a focal point for implementation efforts to
maximise the individual and public health benefits of antiretroviral therapy. We aimed to …

Planning an intervention to prevent infections with the human immunodeficiency virus (HIV)
should be guided by local epidemiological and socioeconomic conditions. The …

Debate ensued when mathematical models1 predicted that universal testing and treatment
could achieve epidemic control within a few years in a high-burden setting. However, the …

Background Expanded access to antiretroviral therapy (ART) using universal test and treat
(UTT) has been suggested as a strategy to eliminate HIV in South Africa within 7 y based on …

Background Many mathematical models have investigated the impact of expanding access
to antiretroviral therapy (ART) on new HIV infections. Comparing results and conclusions …