The mechanism by which ubiquitination of histone H2B (H2Bub1) regulates H3-K4 and-K79
methylation and the histone H2A-H2B chaperone Spt16-mediated nucleosome dynamics …

Regulation of Set1-COMPASS-mediated H3K4 methylation and Dot1-mediated H3K79
methylation by H2BK123 ubiquitination (H2Bub1) is an evolutionarily conserved trans …

Monoubiquitylation of histone H2B (H2Bub1), catalyzed by the heterodimeric ubiquitin
ligase complex RNF20/40, regulates multiple molecular and biological processes. The …

Functional centromeres are essential for proper cell division. Centromeres are established
largely by epigenetic processes resulting in incorporation of the histone H3 variant CENP-A …

Regulation of chromatin structure involves histone posttranslational modifications that can
modulate intrinsic properties of the chromatin fiber to change the chromatin state. We used …

Ubiquitylation of histone H2B at lysine 120 (H2B-Ub) plays a critical role in transcriptional
elongation, chromatin conformation, as well as the regulation of specific histone H3 …

The COMPASS (complex of proteins associated with Set1) complex represents the prototype
of the SET1/MLL family of methyltransferases that controls gene transcription by H3K4 …

The structure of eukaryotic chromatin directly influences gene function, and is regulated by
chemical modifications of the core histone proteins. Modification of the human histone H4 N …

Simple Summary Post-translational modifications (PTM) of histone tails represent
epigenomic regulation of the chromatin landscape, influencing gene expression and the …

The post-translational modification of histone proteins plays an important role in controlling
cell fate by directing essentially all DNA-associated nuclear processes. Misregulation and …