Activation of the transcription factor nuclear factor kappa B (NF-κB) is controlled by
sequential phosphorylation, ubiquitination, and degradation of its inhibitory subunit IκB. A …

IκB [inhibitor of nuclear factor κB (NF-κB)] kinase (IKK) phosphorylates IκB inhibitory
proteins, causing their degradation and activation of transcription factor NF-κB, a master …

Activation of the transcription factor nuclear factor kappa B (NF-κB) by inflammatory
cytokines requires the successive action of NF-κB–inducing kinase (NIK) and IκB kinase–α …

A large protein complex mediates the phosphorylation of the inhibitor of κB (IκB), which
results in the activation of nuclear factor κB (NF-κB). Two subunits of this complex, IκB kinase …

Nuclear factor kappa B (NF-κB)/Rel proteins are dimeric, sequence-specific transcription
factors involved in the activation of an exceptionally large number of genes in response to …

In mammals, the canonical nuclear factor κB (NF-κB) signaling pathway activated in
response to infections is based on degradation of IκB inhibitors. This pathway depends on …

NF-κB is a principal transcriptional regulator of diverse cytokine-mediated processes and is
tightly controlled by the IκB kinase complex (IKK-α/β/γ). IKK-β and IKK-γ are critical for …

The nuclear factor–kappa B (NF-κB) family of transcription factors plays a seminal role in
inflammation, apoptosis, development, and cancer. Modulation of NF-κB–mediated gene …

One of the most intensely studied regulators of gene expression is the transcription factor NF-
κB. NF-κB activates groups of genes in response to a wide array of extracellular factors …

Nuclear transcription factors of the NF-κB/Rel family are inhibited by IκB proteins, which
inactivate NF-κB by trapping it in the cell cytoplasm. Phosphorylation of IκBs marks them out …