Cells maintain organellar pools of “labile iron”(LI), despite its propensity for catalyzing the
formation of reactive oxygen species. These pools are identifiable by iron-chelating probes …

Iron is indispensible for life, essential for such processes as oxygen transport, electron
transfer, and DNA synthesis. Because of iron's virtual insolubility and potential toxicity …

Iron acquired by cells is delivered to mitochondria for metabolic processing via pathways
comprising undefined chemical forms. In order to assess cytosolic factors that affect those …

In living systems iron appears predominantly associated with proteins, but can also be
detected in forms referred as labile iron, which denotes the combined redox properties of …

Maintenance of proper “labile iron” levels is a critical component in preserving homeostasis.
Iron is a vital element that is a constituent of a number of important macromolecules …

Eukaryotic cells contain hundreds of proteins that require iron cofactors for activity. These
iron enzymes are located in essentially every subcellular compartment; thus, iron cofactors …

205 (4), 297-318── Iron is fastidiously utilized by living cells, since it is an essential
element, but is toxic in excess. Cells take up iron via a transferrin-transferrin receptor …

To maintain an adequate iron supply for hemoglobin synthesis and essential metabolic
functions while counteracting iron toxicity, humans and other vertebrates have evolved …

Non-transferrin-bound iron, commonly found in the plasma of iron-overloaded individuals,
permeates into cells via pathways independent of the transferrin receptor. This may lead to …

Iron is an essential but potentially hazardous biometal. Mammalian cells require sufficient
amounts of iron to satisfy metabolic needs or to accomplish specialized functions. Iron is …