Astaxanthin enhances the development of bovine cloned embryos by inhibiting apoptosis and improving DNA methylation reprogramming of pluripotency genes

F Bi, H Xiang, J Li, J Sun, N Wang, W Gao, M Sun… - Theriogenology, 2023 - Elsevier
Low cloning efficiency limits the wide application of somatic cell nuclear transfer technology.
Apoptosis and incomplete DNA methylation reprogramming of pluripotency genes are …

Astaxanthin normalizes epigenetic modifications of bovine somatic cell cloned embryos and decreases the generation of lipid peroxidation

R Li, H Wu, WW Zhuo, QF Mao, H Lan… - … in Domestic Animals, 2015 - Wiley Online Library
Contents Astaxanthin is an extremely common antioxidant scavenging reactive oxygen
species (ROS) and blocking lipid peroxidation. This study was conducted to investigate the …

DNA methylation regulated by ascorbic acids in yak preimplantation embryo helps to improve blastocyst quality

Q Li, Y Pan, H He, X Hu, T Zhao, J Jiang… - Molecular …, 2019 - Wiley Online Library
DNA methylation as an important, essential epigenetic modification is critical for the
successful development of mammalian embryos. In recent years, the important role of …

Epigenetic modification agents improve genomic methylation reprogramming in porcine cloned embryos

YJ Huan, J Zhu, HM Wang, ZF Wu… - … of Reproduction and …, 2014 - jstage.jst.go.jp
Incomplete DNA methylation reprogramming in cloned embryos leads to low cloning
efficiency. Our previous studies showed that the epigenetic modification agents 5-aza-2' …

Melatonin enhances the development of porcine cloned embryos by improving DNA methylation reprogramming

J Qu, M Sun, X Wang, X Song, H He… - Cellular …, 2020 - liebertpub.com
Incomplete DNA methylation reprogramming in cloned embryos leads to poor cloning
efficiency. Melatonin has been proven to improve the development of cloned embryos …

Astaxanthin supplementation improves the subsequent developmental competence of vitrified porcine zygotes

D Xiang, B Jia, B Zhang, J Liang, Q Hong… - Frontiers in Veterinary …, 2022 - frontiersin.org
Cryopreservation of embryos has been confirmed to cause oxidative stress as a factor
responsible for impaired developmental competence. Currently, astaxanthin (Ax) raises …

Optimizing 5-aza-2′-deoxycytidine treatment to enhance the development of porcine cloned embryos by inhibiting apoptosis and improving DNA methylation …

J Qu, X Wang, Y Jiang, X Lv, X Song, H He… - Research in Veterinary …, 2020 - Elsevier
Apoptosis and incomplete DNA methylation reprogramming in cloned embryos reduce
cloning efficiency. 5-aza-2′-deoxycytidine (5-aza-dC) is proven to regulate apoptosis and …

TSA improve transgenic porcine cloned embryo development and transgene expression

QR Kong, J Zhu, B Huang, YJ Huan, F Wang… - Yi Chuan …, 2011 - europepmc.org
Uncompleted epigenetic reprogramming is attributed to the low efficiency of producing
transgenic cloned animals. Histone modification associated with epigenetics can directly …

Treatments of porcine nuclear recipient oocytes and somatic cell nuclear transfer-generated embryos with various reactive oxygen species scavengers Lead to …

SH Oh, SE Lee, DH Han, JW Yoon, SH Kim… - Cellular …, 2023 - liebertpub.com
This study investigated the antioxidant effects of β-cryptoxanthin (BCX), hesperetin (HES),
and icariin (ICA), and their effects on in vitro maturation of porcine oocytes and subsequent …

Asiatic acid supplementation during the in vitro culture period improves early embryonic development of porcine embryos produced by parthenogenetic activation …

JJ Qi, XX Li, YF Diao, PL Liu, DL Wang, CY Bai, B Yuan… - Theriogenology, 2020 - Elsevier
Asiatic acid is a pentacyclic triterpene enriched in the medicinal herb Centella asiatica, and
it has been suggested to possess free radical scavenging and anti-apoptotic properties. The …