The present study evaluated the effect of Scriptaid, a novel histone deacetylase inhibitor
(HDACi), on the in vitro development of somatic cell nuclear transfer (SCNT) bovine …

Reprogramming of somatic DNA by oocytes is inadequate and thus often causes an
abnormal epigenetic status in embryos derived from somatic cell nuclear transfer (SCNT) …

Nuclear reprogramming induced by somatic cell nuclear transfer is an inefficient process,
and donor cell DNA methylation status is thought to be a major factor affecting cloning …

Accumulating evidence suggests that aberrant epigenetic reprogramming and low
pluripotency of donor nuclei lead to abnormal development of cloned embryos and underlie …

Until now, the efficiency of animal cloning by somatic cell nuclear transfer (SCNT) has
remained low. Efforts to improve cloning efficiency have demonstrated a positive role of …

Somatic cell nuclear transfer (SCNT) is a useful technology; however, its efficiency is low. In
this study, we investigated the effects of cytoplasmic transfer into enucleated oocytes on the …

Bovine embryos are typically cultured at reduced oxygen tension to lower the impact of
oxidative stress on embryo development. However, oocyte in vitro maturation (IVM) is …

Impaired development of embryos produced by somatic cell nuclear transfer (SCNT) is
mostly associated with faulty reprogramming of the somatic nucleus to a totipotent state and …

Somatic cell nuclear transfer (SCNT) has shown tremendous potential for understanding the
mechanisms of reprogramming and creating applications in the realms of agriculture …

Faulty epigenetic reprogramming of somatic nuclei is likely to be a major cause of low
success observed in all mammals produced through somatic cell nuclear transfer (SCNT). It …