Realistic mathematical models of biochemical pathways require kinetic data that have been
measured under physiological conditions. However, until recently most enzyme-kinetic data …

Many in vivo enzymatic processes, such as those of the tissue factor pathway of blood
coagulation, occur in environments with facilitated substrate delivery or enzymes bound to …

The goal of realistically and reliably simulating the biochemical processes underlying
cellular function is achievable through a systematic approach that makes use of the broadest …

Over the past 100 years, deterministic rate equations have been successfully used to infer
enzyme‐catalysed reaction mechanisms and to estimate rate constants from reaction …

Background The mechanistic description of enzyme kinetics in a dynamic model of
metabolism requires specifying the numerical values of a large number of kinetic …

In areas such as drug development, clinical diagnosis and biotechnology research,
acquiring details about the kinetic parameters of enzymes is crucial. The correct design of an …

The dynamics of how the constituent components of a natural system interact defines the
spatio-temporal response of the system to stimuli. Modeling the kinetics of the processes that …

A decade ago, a team of biochemists including two of us, modeled yeast glycolysis and
showed that one of the most studied biochemical pathways could not be quite understood in …

Enzymology is concerned with the study of enzyme structure, function, regulation and
kinetics. It is an interdisciplinary subject that can be treated as an exclusive sphere of …

Much of enzyme kinetics builds on simplifications enabled by the quasi‐steady‐state
approximation and is highly useful when the concentration of the enzyme is much lower than …