Activated phosphoinositide 3-kinase delta syndrome (APDS), also known as p110 delta-
activating mutation causing senescent T cells, lymphadenopathy and immunodeficiency …

The activated phosphoinositide 3-kinase δ syndrome (APDS), also known as p110δ-
activating mutation causing senescent T cells, lymphadenopathy, and immunodeficiency …

Highlights•APDS is caused by activating mutations in PIK3CD or PIK3R1 encoding PI3Kδ
subunits.•Recurrent infection, lymphoproliferation, and immunopathology occur in …

Primary immunodeficiencies are inherited disorders of the immune system, often caused by
the mutation of genes required for lymphocyte development and activation. Recently …

Activated PI3Kδ Syndrome (APDS) is an inherited immune disorder caused by
heterozygous, gain-of-function mutations in the genes encoding the phosphoinositide 3 …

Background Activated phosphoinositide 3-kinase δ syndrome (APDS) 2 (p110δ-activating
mutations causing senescent T cells, lymphadenopathy, and immunodeficiency [PASLI] …

Pathogenic gain-of-function mutations in the gene encoding phosphoinositide 3-kinase
delta (PI3Kδ) cause activated PI3Kδ syndrome (APDS), a disease characterized by humoral …

The p110δ subunit of phosphoinositide 3-kinase (PI (3) K) is selectively expressed in
leukocytes and is critical for lymphocyte biology. Here we report three different germline …

Activated PI3K Delta Syndrome (APDS) is a primary immunodeficiency disease caused by
activating mutations in either the leukocyte-restricted p110δ catalytic (PIK3CD) subunit or …

Activated phosphoinositide 3-kinase (PI3K) δ Syndrome (APDS), caused by autosomal
dominant mutations in PIK3CD (APDS1) or PIK3R1 (APDS2), is a heterogeneous primary …