Multi-cellular spheroids mimic the complex three-dimensional environment of natural
tissues. Accordingly, they are also used as vascularization units in angiogenesis research …

Spheroids are increasingly being employed to answer a wide range of clinical and
biomedical inquiries ranging from pharmacology to disease pathophysiology, with the …

Many types of mammalian cells can aggregate and differentiate into 3‐D multicellular
spheroids when cultured in suspension or a nonadhesive environment. Compared to …

Spheroids provide a 3D environment with intensive cell–cell contacts. As a result of their
excellent regenerative properties and rapid progress in their high-throughput production …

A spheroid is a complex, spherical cellular aggregate supporting cell-cell and cell-matrix
interactions in an environment that mimics the real-world situation. In terms of tissue …

Abstract Three-dimensional (3D) cell culture has tremendous advantages to closely mimic
the in vivo architecture and microenvironment of healthy tissue and organs, as well as of …

Engineering of in vitro three-dimensional cultures of stem cells and their progenies has
offered promising alternatives to recapitulate the in vivo microenvironment, or stem cell …

Introduction: Developing in vitro models for studying cell biology and cell physiology is of
great importance to the fields of biotechnology, cancer research, drug discovery, toxicity …

Multi‐cellular spheroids are formed as a 3D structure with dense cell–cell/cell–extracellular
matrix interactions, and thus, have been widely utilized as implantable therapeutics and …

Cell therapies offer a tailorable, personalized treatment for use in tissue engineering to
address defects arising from trauma, inefficient wound repair, or congenital malformation …