New 1, 3, 4‐oxadiazoles linked with the 1, 2, 3‐triazole moiety as antiproliferative agents targeting the EGFR tyrosine kinase
Abstract A series of 1, 3, 4‐oxadiazole‐1, 2, 3‐triazole hybrids bearing different
pharmacophoric moieties has been designed and synthesized. Their antiproliferative activity …
pharmacophoric moieties has been designed and synthesized. Their antiproliferative activity …
Naproxen based 1, 3, 4-oxadiazole derivatives as EGFR inhibitors: Design, synthesis, anticancer, and computational studies
MM Alam, S Nazreen, ASA Almalki, AA Elhenawy… - Pharmaceuticals, 2021 - mdpi.com
A library of novel naproxen based 1, 3, 4-oxadiazole derivatives (8–16 and 19–26) has been
synthesized and screened for cytotoxicity as EGFR inhibitors. Among the synthesized …
synthesized and screened for cytotoxicity as EGFR inhibitors. Among the synthesized …
Design, synthesis and molecular docking studies of new Quinoxaline-linked-1, 2, 4-triazole-Sulfonamide hybrids as Anti-proliferative agents
MR Nallapu, R Vadluri, J Arasan - Chemical Biology Letters, 2022 - pubs.thesciencein.org
A new series of quinoxaline linked 1, 2, 4-triazole sulfonamide derivatives were designed
and efficiently synthesized. All compounds were characterized by their IR, 1HNMR …
and efficiently synthesized. All compounds were characterized by their IR, 1HNMR …
In‐vitro Anticancer and Molecular Docking Studies of 4‐Azaindole‐1, 2, 4‐Oxadiazole Hybrids
RR Sagam, SK Nukala, R Nagavath, N Sirassu… - …, 2021 - Wiley Online Library
The synthesis of some novel 4‐azaindole‐1, 2, 4‐oxadiazole hybrids (5 a–5 q) from the
reaction between 1H‐pyrrolo [3, 2‐b] pyridine‐3‐carbonitrile and readily available aromatic …
reaction between 1H‐pyrrolo [3, 2‐b] pyridine‐3‐carbonitrile and readily available aromatic …
Design, synthesis, and antiproliferative activities of novel substitutedhydrazone/triazolo-linked quinazoline derivatives
A series of novel hydrazonoquinazolines and triazoloquinazolines analogues of Erlotinib
were synthesized and evaluated for their antiproliferative as well as EGFR kinase inhibitory …
were synthesized and evaluated for their antiproliferative as well as EGFR kinase inhibitory …
Design, synthesis and biological evaluation of pyrazolyl-nitroimidazole derivatives as potential EGFR/HER-2 kinase inhibitors
XX Tao, YT Duan, LW Chen, DJ Tang, MR Yang… - Bioorganic & Medicinal …, 2016 - Elsevier
A series of novel pyrazole-nitroimidazole derivatives had been arranged and evaluated for
their EGFR/HER-2 tyrosine kinase inhibitory activity as well as their antiproliferative …
their EGFR/HER-2 tyrosine kinase inhibitory activity as well as their antiproliferative …
Synthesis and biological evaluation of novel [1, 2, 3] triazolo-pyrrolo [1, 2-a] pyrido [4, 3-d] pyrimidines as EGFR targeting anticancer agents
SR Bandi, N Kavitha, SK Nukala… - Journal of Molecular …, 2023 - Elsevier
Herein, we synthesized some new fused [1, 2, 3] triazolo-pyrrolo [1, 2-a] pyrido [4, 3-d]
pyrimidines via click chemistry followed by carbon-carbon bond coupling as key approach …
pyrimidines via click chemistry followed by carbon-carbon bond coupling as key approach …
Synthesis and biological evaluation of pyrazole derivatives containing thiourea skeleton as anticancer agents
PC Lv, HQ Li, J Sun, Y Zhou, HL Zhu - Bioorganic & medicinal chemistry, 2010 - Elsevier
Two series of pyrazole derivatives designing for potential EGFR kinase inhibitors have been
discovered. Some of them exhibited significant EGFR inhibitory activity. Compound 3-(3, 4 …
discovered. Some of them exhibited significant EGFR inhibitory activity. Compound 3-(3, 4 …
Arylidenes of Quinolin-2-one scaffold as Erlotinib analogues with activities against leukemia through inhibition of EGFR TK/STAT-3 pathways
MAI Elbastawesy, M Ramadan, YAMM El-Shaier… - Bioorganic …, 2020 - Elsevier
A new series of 6-substiuted-4-(2-(4-substituted-benzylidene) hydrazinyl) quinolin-2 (1H)-
one derivatives have been designed and synthesized. The structure of the synthesized …
one derivatives have been designed and synthesized. The structure of the synthesized …
Synthesis and In Vitro Antitumor Activity Evaluation of Gefitinib-1, 2, 3-Triazole Derivatives
Z Liu, J Liu, E Gao, L Mao, S Hu, S Li - Molecules, 2024 - mdpi.com
In this study, 14 structurally novel gefitinib-1, 2, 3-triazole derivatives were synthesized using
a click chemistry approach and characterized by 1H NMR, 13C NMR and high-resolution …
a click chemistry approach and characterized by 1H NMR, 13C NMR and high-resolution …