Here, we present the design, synthesis, and evaluation of a new series of 1H-benzo [d]
imidazole derivatives (10a–j) to determine their anticancer efficacy. The MCF-7 and HCT116 …

Preclinical Research A series of novel carbohydrate‐derived Erlotinib derivatives were
prepared by the copper‐catalyzed cycloaddition reaction of erlotinib with various azido …

A series of 1H-1, 2, 3-triazole-4H-chromene-D-glucose hybrid compounds 7a-o was
synthesized via click chemistry using 2-amino-7-propargyloxy-4H-chromene-3-carbonitriles …

Epidermal growth factor receptor (EGFR, also known as HER1) and HER2, prominent
members of receptor tyrosine kinase (RTK) superfamily, have been reported as diagnostic or …

Herein, we synthesized some new indole-1, 3, 4-oxadiazole based sulfonyl 1, 2, 3-triazoles
via a click chemistry approach and then characterized their structures by NMR, mass, and …

A series of novel compounds carrying 1, 2, 4-triazole scaffold were prepared and evaluated
for their antiproliferative activities against NCI 60 cell line. Compounds 10 (a, c), 11 (ad), and …

Two series of thiazolidinone derivatives designing for potential EGFR and HER-2 kinase
inhibitors have been discovered. Some of them exhibited significant EGFR and HER-2 …

This study was focused on the synthesis of new pyrimidines 4a, b, 5a, b and pyrazoles 6a, b
as ATP mimicking tyrosine kinase inhibitors of the epidermal growth factor receptor (EGFR) …

Herein, we prepared some new imidazole-1, 2, 4-oxadiazole hybrids (6a–6o) and
investigated their antiproliferative potential on three human cancer cell lines (HepG2, A549 …

The in vitro anticancer efficacy of a new series of quinazoline-based thiazole derivatives was
explored. Three cancer cell lines, MCF-7, HepG2, and A548, as well as the normal Vero cell …