Design, synthesis, and antitumor activity of novel quinazoline derivatives
L Wang, P Li, B Li, Y Wang, J Li, L Song - Molecules, 2017 - mdpi.com
In an attempt to explore a new class of epidermal growth factor receptor (EGFR) inhibitors,
novel 4-stilbenylamino quinazoline derivatives were synthesized through a Dimorth …
novel 4-stilbenylamino quinazoline derivatives were synthesized through a Dimorth …
Synthesis of 4-Azaindole-Thiazolidine-2, 4-Dione Coupled 1, 2, 3-Triazoles as EGFR Directing Anticancer Agents
T Shreedhar Reddy, S Rai… - Polycyclic Aromatic …, 2023 - Taylor & Francis
Herein, we synthesized some new 4-azaindole-thiazolidine-2, 4-dione-1, 2, 3-triazole
hybrids (6a-6n) via Knoevenagel condensation and copper (I) catalyzed azide-alkyne …
hybrids (6a-6n) via Knoevenagel condensation and copper (I) catalyzed azide-alkyne …
Novel benzothiazole hybrids targeting EGFR: Design, synthesis, biological evaluation and molecular docking studies
EA Abd El-Meguid, GO Moustafa, HM Awad… - Journal of Molecular …, 2021 - Elsevier
Novel benzo [d] thiazole-based analogues were synthesized with the aim of screening their
in vitro anticancer activity. All the new derivatives 4–21 were evaluated against human …
in vitro anticancer activity. All the new derivatives 4–21 were evaluated against human …
Design, synthesis, biological evaluation, QSAR analysis and molecular modelling of new thiazol-benzimidazoles as EGFR inhibitors
AM Srour, NS Ahmed, SS Abd El-Karim… - Bioorganic & Medicinal …, 2020 - Elsevier
Heterocyclic rings such as thiazole and benzimidazole are considered as privileged
structures, since they constitute several FDA-approved drugs for cancer treatment. In this …
structures, since they constitute several FDA-approved drugs for cancer treatment. In this …
Novel 2‐[thio] acetamide linked quinazoline/1, 2, 4‐triazole/chalcone hybrids: Design, synthesis, and anticancer activity as EGFR inhibitors and apoptotic inducers
Novel triazoloquinazolines carrying the 2‐[thio] acetamide entity (4 and 5a–d) and
triazoloquinazoline/chalcone hybrids incorporating the 2‐[thio] acetamide linker (8a–b and …
triazoloquinazoline/chalcone hybrids incorporating the 2‐[thio] acetamide linker (8a–b and …
Computational design, synthesis, and assessment of 3-(4-(4-(1, 3, 4-oxadiazol-2-yl)-1 H-imidazol-2-yl) phenyl)-1, 2, 4-oxadiazole derivatives as effective epidermal …
NR Khedkar, M Sindkhedkar, A Joseph - RSC Medicinal Chemistry, 2024 - pubs.rsc.org
The epidermal growth factor receptor (EGFR) enzyme plays a critical role in governing the
cell cycle, positioning it as a promising target for the development of anticancer drugs. In this …
cell cycle, positioning it as a promising target for the development of anticancer drugs. In this …
Pyridine-Based Glycosides Bearing 1, 2, 4-Triazole and Their 1, 3, 4-oxadiazole analogues as Potential EGFR and CDK-2 Inhibitors: Design, Synthesis …
AF Kassem, A Younis, ES Nossier, HM Awad… - Journal of Molecular …, 2024 - Elsevier
The increasing toxicity of recently developed anticancer medications is seen as a serious
problem that stems from the variety of targets involved; as a result, more research on these …
problem that stems from the variety of targets involved; as a result, more research on these …
Novel benzothiazole-based dual VEGFR-2/EGFR inhibitors targeting breast and liver cancers: Synthesis, cytotoxic activity, QSAR and molecular docking studies
EA Abd El-Meguid, AM Naglah, GO Moustafa… - Bioorganic & Medicinal …, 2022 - Elsevier
A novel series of benzothiazole-based derivatives linked to various amino acids and their
corresponding ethyl ester analogues were prepared and were initially evaluated for their …
corresponding ethyl ester analogues were prepared and were initially evaluated for their …
Novel series of 6-(2-substitutedacetamido)-4-anilinoquinazolines as EGFR-ERK signal transduction inhibitors in MCF-7 breast cancer cells
RSM Ismail, SM Abou-Seri, WM Eldehna… - European Journal of …, 2018 - Elsevier
Epidermal growth factor receptor (EGFR) signaling pathway has been previously
investigated for its significant role in the progression of different types of malignant tumors …
investigated for its significant role in the progression of different types of malignant tumors …
Design and synthesis of novel quinoline/chalcone/1, 2, 4-triazole hybrids as potent antiproliferative agent targeting EGFR and BRAFV600E kinases
New quinoline/chalcone hybrids containing 1, 2, 4-triazole moiety have been designed,
synthesized and their structures elucidated and confirmed by various spectroscopic …
synthesized and their structures elucidated and confirmed by various spectroscopic …