Design, synthesis and docking studies of benzimidazole derivatives as potential EGFR inhibitors
In this study, a series of benzimidazoles bearing thiosemicarbazide chain or triazole and
thiadiazole rings were designed and synthesized. Crystal and molecular structure of the …
thiadiazole rings were designed and synthesized. Crystal and molecular structure of the …
Discovery of novel pyrazole based Urea/Thiourea derivatives as multiple targeting VEGFR-2, EGFRWT, EGFRT790M tyrosine kinases and COX-2 Inhibitors, with anti …
WAA Fadaly, MTM Nemr, NM Kahk - Bioorganic Chemistry, 2024 - Elsevier
A novel series of pyrazole derivatives with urea/thiourea scaffolds 16a-l as hybrid
sorafenib/erlotinib/celecoxib analogs was designed, synthesized and tested for its VEGFR-2 …
sorafenib/erlotinib/celecoxib analogs was designed, synthesized and tested for its VEGFR-2 …
Design and Synthesis of some new 2, 4, 6-trisubstituted quinazoline EGFR inhibitors as targeted anticancer agents
HA Allam, EE Aly, AK Farouk, AM El Kerdawy… - Bioorganic …, 2020 - Elsevier
The present study describes the synthesis of 6-bromo-2-(pyridin-3-yl)-4-substituted
quinazolines starting from 4-chloro derivative VI via the reaction with either phenolic …
quinazolines starting from 4-chloro derivative VI via the reaction with either phenolic …
Novel quinazolin‐4(3H)‐one linked to 1,2,3‐triazoles: Synthesis and anticancer activity
In this work, a wide range of novel quinazolin‐4 (3H)‐one linked to 1, 2, 3‐triazoles was
designed, synthesized, and evaluated against a panel of three human breast (MDA‐MB …
designed, synthesized, and evaluated against a panel of three human breast (MDA‐MB …
[HTML][HTML] Synthesis, Characterization, and Biological Activity of a Novel Series of Benzo[4,5]imidazo[2,1-b]thiazole Derivatives as Potential Epidermal Growth Factor …
X Deng, X Tan, T An, Q Ma, Z Jin, C Wang, Q Meng… - Molecules, 2019 - mdpi.com
Based on the analysis of epidermal growth factor receptor (EGFR) complexes with gefitinib
with molecular docking, the scaffold-hopping strategy, combination of the active …
with molecular docking, the scaffold-hopping strategy, combination of the active …
Synthesis and biological evaluation of compounds which contain pyrazole, thiazole and naphthalene ring as antitumor agents
JW Yuan, SF Wang, ZL Luo, HY Qiu, PF Wang… - Bioorganic & medicinal …, 2014 - Elsevier
A series of compounds which contain pyrazole, thiazole and naphthalene ring (1a–7a, 1b–
7b, 1c–7c, 1d–7d) were firstly synthesized and their anti-proliferative activity, EGFR …
7b, 1c–7c, 1d–7d) were firstly synthesized and their anti-proliferative activity, EGFR …
Novel diphenylamine 2, 4′-dicarboxamide based azoles as potential epidermal growth factor receptor inhibitors: synthesis and biological activity
Several hybrid molecules of diphenylamine-2, 4-dicarboxamide with various azolidinones
and related heterocyclic rings have been synthesized and explored as epidermal growth …
and related heterocyclic rings have been synthesized and explored as epidermal growth …
Synthesis of a new series of 4-pyrazolylquinolinones with apoptotic antiproliferative effects as dual EGFR/BRAF V600E inhibitors
The current study focuses on developing a single molecule that acts as an antiproliferative
agent with dual or multi-targeted action, reducing drug resistance and adverse effects. A …
agent with dual or multi-targeted action, reducing drug resistance and adverse effects. A …
Synthesis and Anticancer Activities of Pyrazole–Thiadiazole-Based EGFR Inhibitors
Lung cancer is one of the most common cancer types of cancer with the highest mortality
rates. However, while epidermal growth factor receptor (EGFR) is an important parameter for …
rates. However, while epidermal growth factor receptor (EGFR) is an important parameter for …
Design, synthesis, and apoptotic antiproliferative action of new 1, 2, 3-triazole/1, 2, 4-oxadiazole hybrids as dual EGFR/VEGFR-2 inhibitors
Abstract A novel series of 1, 2, 3-triazole/1, 2, 4-oxadiazole hybrids (7a–o) was developed
as dual inhibitors of EGFR/VEGFR-2. Compounds 7a–o were evaluated as antiproliferative …
as dual inhibitors of EGFR/VEGFR-2. Compounds 7a–o were evaluated as antiproliferative …