Truncating mutations in NRXN2 and NRXN1 in autism spectrum disorders and schizophrenia
J Gauthier, TJ Siddiqui, P Huashan, D Yokomaku… - Human genetics, 2011 - Springer
Growing genetic evidence is converging in favor of common pathogenic mechanisms for
autism spectrum disorders (ASD), intellectual disability (ID or mental retardation) and …
autism spectrum disorders (ASD), intellectual disability (ID or mental retardation) and …
Recent genomic advances in schizophrenia
JL Doherty, MC O'Donovan, MJ Owen - Clinical genetics, 2012 - Wiley Online Library
Doherty JL, O'Donovan MC, Owen MJ. Recent genomic advances in schizoprenia. Recent
studies have supported the hypothesis based upon expectations from population genetics …
studies have supported the hypothesis based upon expectations from population genetics …
Human neuropsychiatric disease modeling using conditional deletion reveals synaptic transmission defects caused by heterozygous mutations in NRXN1
Heterozygous mutations of the NRXN1 gene, which encodes the presynaptic cell-adhesion
molecule neurexin-1, were repeatedly associated with autism and schizophrenia. However …
molecule neurexin-1, were repeatedly associated with autism and schizophrenia. However …
Intragenic rearrangements in NRXN1 in three families with autism spectrum disorder, developmental delay, and speech delay
B Wiśniowiecka‐Kowalnik, M Nesteruk… - American Journal of …, 2010 - Wiley Online Library
NRXN1 is highly expressed in brain and has been shown recently to be associated with
ASD, schizophrenia, cognitive and behavioral abnormalities, and alcohol and nicotine …
ASD, schizophrenia, cognitive and behavioral abnormalities, and alcohol and nicotine …
Neurexins in autism and schizophrenia—a review of patient mutations, mouse models and potential future directions
A Tromp, B Mowry, J Giacomotto - Molecular psychiatry, 2021 - nature.com
Mutations in the family of neurexins (NRXN1, NRXN2 and NRXN3) have been repeatedly
identified in patients with autism spectrum disorder (ASD) and schizophrenia (SCZ) …
identified in patients with autism spectrum disorder (ASD) and schizophrenia (SCZ) …
Deletions of NRXN1 (neurexin‐1) predispose to a wide spectrum of developmental disorders
Research has implicated mutations in the gene for neurexin‐1 (NRXN1) in a variety of
conditions including autism, schizophrenia, and nicotine dependence. To our knowledge …
conditions including autism, schizophrenia, and nicotine dependence. To our knowledge …
Genetic insights and neurobiological implications from NRXN1 in neuropsychiatric disorders
Many neuropsychiatric and neurodevelopmental disorders commonly share genetic risk
factors. To date, the mechanisms driving the pathogenesis of these disorders, particularly …
factors. To date, the mechanisms driving the pathogenesis of these disorders, particularly …
Disruption of the neurexin 1 gene is associated with schizophrenia
Deletions within the neurexin 1 gene (NRXN1; 2p16. 3) are associated with autism and have
also been reported in two families with schizophrenia. We examined NRXN1, and the …
also been reported in two families with schizophrenia. We examined NRXN1, and the …
Phenotypic spectrum and genotype–phenotype correlations of NRXN1 exon deletions
Copy number variants (CNVs) and intragenic rearrangements of the NRXN1 (neurexin 1)
gene are associated with a wide spectrum of developmental and neuropsychiatric disorders …
gene are associated with a wide spectrum of developmental and neuropsychiatric disorders …
Genetic targeting of NRXN2 in mice unveils role in excitatory cortical synapse function and social behaviors
G Born, HM Grayton, H Langhorst… - Frontiers in synaptic …, 2015 - frontiersin.org
Human genetics has identified rare copy number variations and deleterious mutations for all
neurexin genes (NRXN1-3) in patients with neurodevelopmental diseases, and …
neurexin genes (NRXN1-3) in patients with neurodevelopmental diseases, and …