Background Genomic hybridization platforms, including BAC-CGH and genotyping arrays,
have been used to estimate chromosome copy number (CN) in tumor samples by detecting …

We have undertaken an extensive high‐resolution analysis of loss of heterozygosity (LOH)
in 30 high grade gliomas using the Affymetrix 100K SNP mapping array. Only 70% of LOH …

Copy number abnormalities (CNAs) in tumor cells are presumed to affect expression levels
of genes located in region of abnormality. To investigate this relationship we have surveyed …

Chromosomal gains and losses comprise an important type of genetic change in tumors,
and can now be assayed using microarray hybridization-based experiments. Most current …

Glioblastomas are morphologically and genetically heterogeneous, but little is known about
the regional patterns of genomic imbalance within glioblastomas. We recently established a …

Primary brain tumors are the fourth leading cause of cancer mortality in adults under the age
of 54 years and the leading cause of cancer mortality in children in the United States …

Glioblastomas are cytogenetically heterogeneous tumors that frequently display alterations
of chromosomes 7, 9p, and 10q. We used high-density (500K) single-nucleotide …

Identification of genetic copy number changes in glial tumors is of importance in the context
of improved/refined diagnostic, prognostic procedures and therapeutic decision-making. In …

Background Conventional cytogenetic and comparative genomic hybridization (CGH)
studies in brain malignancies have shown that glioblastoma multiforme (GBM) is …

Primary brain tumors are a major cause of cancer mortality in the United States. Therapy for
gliomas, the most common type of primary brain tumors, remains suboptimal. The …