Antioxidant therapy in neurologic disease

N Delanty, MA Dichter - Archives of neurology, 2000 - jamanetwork.com
Free radical or oxidative injury may be a fundamental mechanism underlying a number of
human neurologic diseases. Therapy using free radical scavengers (antioxidants) has the …

Antioxidant neuroprotection in Alzheimer's disease as preventive and therapeutic approach

C Behl, B Moosmann - Free Radical Biology and Medicine, 2002 - Elsevier
Various neurodegenerative disorders and syndromes are associated with oxidative stress.
The deleterious consequences of excessive oxidations and the pathophysiological role of …

[HTML][HTML] Disorders of endogenous and exogenous antioxidants in neurological diseases

I Korczowska-Łącka, B Słowikowski, T Piekut, M Hurła… - Antioxidants, 2023 - mdpi.com
In diseases of the central nervous system, such as Alzheimer's disease (AD), Parkinson's
disease (PD), stroke, amyotrophic lateral sclerosis (ALS), Huntington's disease (HD), and …

Antioxidant therapy, oxidative stress, and blood-brain barrier: The road of dietary antioxidants

M Pinto, S Benfeito, C Fernandes, F Borges - Oxidative stress and dietary …, 2020 - Elsevier
Oxidative stress is characterized by an imbalanced redox state that is principally related with
a plethora of radical reactions skilled to trigger several pathophysiological mechanisms. So …

[HTML][HTML] A review on mitochondrial restorative mechanism of antioxidants in Alzheimer's disease and other neurological conditions

A Kumar, A Singh - Frontiers in pharmacology, 2015 - frontiersin.org
Neurodegenerative diseases are intricate in nature because of the involvement of the
multiple pathophysiological events including mitochondrial dysfunction, neuroinflammation …

[HTML][HTML] Oxidative stress, the blood–brain barrier and neurodegenerative diseases: The critical beneficial role of dietary antioxidants

J Feng, Y Zheng, M Guo, I Ares, M Martínez… - … Pharmaceutica Sinica B, 2023 - Elsevier
In recent years, growing awareness of the role of oxidative stress in brain health has
prompted antioxidants, especially dietary antioxidants, to receive growing attention as …

Mechanism of oxidative stress in neurodegeneration

S Gandhi, AY Abramov - Oxidative medicine and cellular …, 2012 - Wiley Online Library
Biological tissues require oxygen to meet their energetic demands. However, the
consumption of oxygen also results in the generation of free radicals that may have …

[HTML][HTML] Oxidative stress and neurodegenerative disorders

J Li, WO, W Li, ZG Jiang, HA Ghanbari - International journal of molecular …, 2013 - mdpi.com
Living cells continually generate reactive oxygen species (ROS) through the respiratory
chain during energetic metabolism. ROS at low or moderate concentration can play …

[HTML][HTML] The role of oxidative stress in neurodegenerative diseases

GH Kim, JE Kim, SJ Rhie, S Yoon - Experimental neurobiology, 2015 - ncbi.nlm.nih.gov
Oxidative stress is induced by an imbalanced redox states, involving either excessive
generation of reactive oxygen species (ROS) or dysfunction of the antioxidant system. The …

Oxidative stress: A target to treat Alzheimer's disease and stroke

S Briyal, AK Ranjan, A Gulati - Neurochemistry International, 2023 - Elsevier
Oxidative stress has been established as a well-known pathological condition in several
neurovascular diseases. It starts with increased production of highly oxidizing free-radicals …