Huangbai liniment accelerated wound healing by activating Nrf2 signaling in diabetes

J Zhang, R Zhou, C Xiang, Q Jia… - … Medicine and Cellular …, 2020 - Wiley Online Library
As a serious complication of diabetes, nonhealing skin ulcer leads to high mortality and
disability in diabetic patients. However, limited therapy is available in managing diabetic …

[HTML][HTML] Huangbai liniment and berberine promoted wound healing in high-fat diet/Streptozotocin-induced diabetic rats

J Zhang, R Zhou, L Deng, G Cao, Y Zhang, H Xu… - Biomedicine & …, 2022 - Elsevier
Diabetic ulcer is a challenging complication of diabetes mellitus but current treatments
cannot achieve satisfactory results. In this study, the effect of Huangbai liniment (HB) and …

Nrf2 suppression delays diabetic wound healing through sustained oxidative stress and inflammation

M Li, H Yu, H Pan, X Zhou, Q Ruan, D Kong… - Frontiers in …, 2019 - frontiersin.org
Impaired wound healing is one of the major complications of diabetes, involving prolonged
inflammation, delayed re-epithelialization, and consistent oxidative stress. The detailed …

Transcriptional profiling and circRNA-miRNA-mRNA network analysis identify the biomarkers in Sheng-ji Hua-yu formula treated diabetic wound healing

Y Xiang, L Kuai, Y Ru, J Jiang, X Li, F Li… - Journal of …, 2021 - Elsevier
Abstract Ethnopharmacological relevance Sheng-ji Hua-yu (SJHY) formula is a traditional
Chinese herbal which is effective in treating diabetic ulcers. It has been indicated to …

Long noncoding RNA–antisense noncoding RNA in the INK4 locus accelerates wound healing in diabetes by promoting lymphangiogenesis via regulating miR‐181a …

ZY He, TH Wei, PH Zhang, J Zhou… - Journal of Cellular …, 2019 - Wiley Online Library
Background Slow lymphangiogenesis is one crucial reason for the impaired wound healing
process in diabetes. Accumulative evidence showed that long noncoding RNA–antisense …

An essential role of NRF2 in diabetic wound healing

M Long, M Rojo de la Vega, Q Wen, M Bharara… - Diabetes, 2016 - Am Diabetes Assoc
The high mortality and disability of diabetic nonhealing skin ulcers create an urgent need for
the development of more efficacious strategies targeting diabetic wound healing. In the …

Fu-Huang ointment ameliorates impaired wound healing associated with diabetes through PI3K-AKT signalling pathway activation

K Qu, Y Ru, D Yang, L Kuai, Y Luo, P Zhang… - Computers in Biology …, 2023 - Elsevier
A diabetic ulcer (DU) is a dreaded and resistant complication of diabetes mellitus with high
morbidity. Fu-Huang ointment (FH ointment) is a proven recipe for treating chronic refractory …

[HTML][HTML] Glucose-responsive, antioxidative HA-PBA-FA/EN106 hydrogel enhanced diabetic wound healing through modulation of FEM1b-FNIP1 axis and promoting …

W Zhang, K Zha, Y Xiong, W Hu, L Chen, Z Lin, C Yu… - Bioactive Materials, 2023 - Elsevier
The diabetic wounds remain to be unsettled clinically, with chronic wounds characterized by
drug-resistant bacterial infections, compromised angiogenesis and oxidative damage to the …

Asiaticoside-nitric oxide promoting diabetic wound healing through the miRNA-21-5p/TGF-β1/SMAD7/TIMP3 signaling pathway

Y Liu, J Zhao, X Mu, J Deng, X Wu, W He, Y Liu… - Journal of …, 2024 - Elsevier
Ethnopharmacological relevance Centella asiatica (L.) Urban is an ethnobotanical herb. The
main bioactive components of Centella asiatica are pentacyclic triterpenoid glycosides …

Beneficial effects of deoxyshikonin on delayed wound healing in diabetic mice

JY Park, MS Shin, GS Hwang, N Yamabe… - International journal of …, 2018 - mdpi.com
Shiunko ointment is composed of five ingredients including Lithospermi Radix (LR),
Angelicae Gigantis Radix, sesame seed oil, beeswax, and swine oil. It is externally applied …