In the adult nervous system, the major source of nucleotide synthesis is the salvage
pathway. Uridine is the major form of pyrimidine nucleosides taken up by the brain. Uridine …

There are many disorders of pyrimidine metabolism and those that involve an alteration in
uridine metabolism have neurological and systemic effects, which provide insights into the …

Uracil nucleotides (ie, UTP and UDP) have been known for years as fundamental
intermediates in the de novo synthesis of the other pyrimidine nucleotides, which altogether …

It is well known that disorders of pyrimidine pathways may lead to neurological,
hematological, immunological diseases, renal impairments, and association with …

Since 1956, when exogenous uridine and cytidine were found to be necessary for the
maintenance of perfused rat brain function, the co-existence of de novo synthesis, salvage …

Increasing evidence for receptors for uracil nucleotides has focused interest on specific
signalling mechanisms involving UTP and UDP. At least three metabotropic P2 receptors …

In addition to their central role in many biochemical processes, uridine nucleotides are
important extracellular signaling molecules that regulate a broad spectrum of cell functions …

Nucleosides, such as uridine, inosine, guanosine and adenosine, may participate in the
regulation of sleep, cognition, memory and nociception, the suppression of seizures, and …

The pyrimidines cytidine (as CTP) and uridine (which is converted to UTP and then CTP)
contribute to brain phosphatidylcholine and phosphatidylethanolamine synthesis via the …

Pyrimidine nucleoside uridine plays a critical role in maintaining cellular function and energy
metabolism. In addition to its role in nucleoside synthesis, uridine and its derivatives …