Gold nanoparticles induce nanostructural reorganization of VEGFR2 to repress angiogenesis

Y Pan, H Ding, L Qin, X Zhao, J Cai… - Journal of biomedical …, 2013 - ingentaconnect.com
The inhibition of the binding between VEGFs and their receptors reduces angiogenesis and
retards tumor growth. Owing to the large amount of antibodies required, the antibody-based …

Inhibition effects of gold nanoparticles on proliferation and migration in hepatic carcinoma-conditioned HUVECs

Y Pan, Q Wu, R Liu, M Shao, J Pi, X Zhao… - Bioorganic & medicinal …, 2014 - Elsevier
Tumor angiogenesis is a complicated process based upon a sequence of interactions
between tumor and vessel endothelial cells. Tumor conditioned medium has been widely …

Gold nanoparticles induce tumor vessel normalization and impair metastasis by inhibiting endothelial Smad2/3 signaling

N Huang, Y Liu, Y Fang, S Zheng, J Wu, M Wang… - ACS …, 2020 - ACS Publications
Gold nanoparticles (AuNPs) are a promising nanomaterial due to their drug-delivery
properties and inherent anti-neoplastic activity. Here, we focused on the anti-neoplastic …

Gold nanoparticles attenuate metastasis by tumor vasculature normalization and epithelial–mesenchymal transition inhibition

W Li, X Li, S Liu, W Yang, F Pan, XY Yang… - International journal …, 2017 - Taylor & Francis
Angiogenesis is a process by which vessels are formed through preexisting ones, and this
plays a key role in the progression of solid tumors. However, tumor vessels are influenced …

Cellular localization and biological effects of 20nm‐gold nanoparticles

G Tan, MA Onur - … of Biomedical Materials Research Part A, 2018 - Wiley Online Library
Gold nanoparticles (AuNPs) have recently emerged as prominent vehicles for many
biomedical applications from sensing to delivery. The relevant literature contains conflicting …

Gold Nanoparticles Inhibit VEGF165‐Induced Migration and Tube Formation of Endothelial Cells via the Akt Pathway

Y Pan, Q Wu, L Qin, J Cai, B Du - BioMed research international, 2014 - Wiley Online Library
The early stages of angiogenesis can be divided into three steps: endothelial cell
proliferation, migration, and tube formation. Vascular endothelial growth factor (VEGF) is …

Synthesis and antitumor application of antiangiogenetic gold nanoclusters

Q Li, R Zhou, Y Sun, D Xiao, M Liu… - … Applied Materials & …, 2021 - ACS Publications
Conventional antiangiogenetic inhibitors suffered from poor delivery problems that result in
unsatisfactory antitumor treatment efficacy. Although the liposomes or nanomaterial-based …

Sorafenib derivatives-functionalized gold nanoparticles confer protection against tumor angiogenesis and proliferation via suppression of EGFR and VEGFR-2

W Huang, Y Xing, L Zhu, J Zhuo, M Cai - Experimental Cell Research, 2021 - Elsevier
Sorafenib is a multi-kinase inhibitor that has been highlighted as a tumor suppressor due to
its anti-proliferative and anti-angiogenic properties, whereas the clinical application of …

Gold Nanoparticles Disrupt Tumor Microenvironment - Endothelial Cell Cross Talk To Inhibit Angiogenic Phenotypes in Vitro

Y Zhang, X Xiong, Y Huai, A Dey… - Bioconjugate …, 2019 - ACS Publications
It is currently recognized that perpetual cross talk among key players in tumor
microenvironment such as cancer cells (CCs), cancer associated fibroblasts (CAFs), and …

Mechanism of anti-angiogenic property of gold nanoparticles: role of nanoparticle size and surface charge

RR Arvizo, S Rana, OR Miranda, R Bhattacharya… - … , biology and medicine, 2011 - Elsevier
Discovering therapeutic inorganic nanoparticles (NPs) is evolving as an important area of
research in the emerging field of nanomedicine. Recently, we reported the anti-angiogenic …