Introduction: It has been known for over half a century that tumors exhibit an increased
demand for nutrients to fuel their rapid proliferation. Interest in targeting cancer metabolism …

Abstract The understanding of 6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 3
(PFK-2/FBPase 3, PFKFB3) has advanced considerably since its initial identification in …

Simple Summary Recently, our understanding of PFK-2 isozymes, particularly with regards
to their roles in cancer, has developed significantly. This review aims to compile the most …

Abstract Fructose-2, 6-bisphosphate (F2, 6BP) is a shunt product of glycolysis that
allosterically activates 6-phosphofructo-1-kinase (PFK-1) resulting in increased glucose …

Reprogrammed metabolism and high energy demand are well-established properties of
cancer cells that enable tumor growth. Glycolysis is a primary metabolic pathway that …

The increased glucose metabolism in cancer cells is required to fulfill their high energetic
and biosynthetic demands. Changes in the metabolic activity of cancer cells are caused by …

phosphofructo-2-kinase/fructose-2, 6-bisphosphatases (PFKFBs) are bifunctional enzymes
which regulate the transformation between fructose-2, 6-bisphosphate (F2, 6BP) and …

Background Cancer cells favor the use of less efficient glycolysis rather than mitochondrial
oxidative phosphorylation to metabolize glucose, even in oxygen-rich conditions, a distinct …

Tumor cells increase glucose metabolism through glycolysis and pentose phosphate
pathways to meet the bioenergetic and biosynthetic demands of rapid cell proliferation. The …

Cancer cells adopt aerobic glycolysis as the major source of energy and biomass production
for fast cell proliferation. The bifunctional enzyme, 6-phosphofructo-2-kinase/fructose-2, 6 …