Background—Low-density lipoprotein (LDL) uptake by monocyte-derived macrophages is a
crucial step in foam cell formation and early atherosclerotic lesion. Increasing evidence …

Aims The formation of foam cells is crucial in the initiation and progression of
atherosclerosis. One of the critical steps in foam cell formation is the uptake of low-density …

The transformation of macrophages into lipid-loaded foam cells is a critical early event in the
pathogenesis of atherosclerosis. Both receptor-mediated uptake of modified LDL, mediated …

The differentiation of macrophages into lipid-laden foam cells is a hallmark in early-stage
atherosclerosis. The developmental role of adenosine monophosphate-activated protein …

Aims Uptake of oxidized lipoprotein particles (oxLDL) and foam cell formation by
macrophages is one of the first steps in the development of atherosclerosis. Recently …

Accumulation of monocytes and the entrapment of oxidized-low-density lipoprotein (ox-LDL)
in monocytes are important in the differentiation into “foam” macrophages and the …

Endocytosis of oxidized low density lipoproteins (oxLDL) by macrophages, mediated by
scavenger receptors, is thought to play a central role in foam cell formation and, thus, in the …

Accumulation of macrophage foam cells in atherosclerotic blood vessel intima is a critical
component of atherogenesis mediated by scavenger receptor-dependent internalization of …

Lipid-laden macrophages are the predominant cell type in the formative stages of
atherosclerosis in most animal models and humans. 1–3 Lipid deposition appears as large …

The formation of low-density lipoprotein (LDL) cholesterol-loaded macrophage foam cells
contributes to the development of atherosclerosis. C-reactive protein (CRP) binds to …