Frontotemporal lobar degeneration (FTLD) represents a collection of neurodegenerative
diseases of frontal and temporal brain regions. It has long been associated with mutations in …

Null mutations in the progranulin gene (PGRN) were recently reported to cause tau-negative
frontotemporal dementia linked to chromosome 17. We assessed the genetic contribution of …

Frontotemporal lobar degeneration (FTLD) refers to a focal, non-Alzheimer form of cerebral
degeneration that encompasses the distinct clinical syndromes of frontotemporal dementia …

Frontotemporal lobar degeneration (FTLD) is a devastating neurodegenerative disease that
is the second most common form of dementia affecting individuals under age 65. The most …

The past year has seen a number of significant advances in our understanding of the
neuropathological and molecular genetic basis of frontotemporal lobar degeneration …

Abstract Ubiquitin‐positive, tau‐negative, frontotemporal dementia (FTD) is caused by null
mutations in progranulin (PGRN; HUGO gene symbol GRN), suggesting a haploinsufficiency …

Background: Mutations in the progranulin gene (PGRN) were identified as the causal
mechanism underlying frontotemporal lobar degeneration (FTLD). Most of these mutations …

Frontotemporal lobar degeneration is the term used to describe the non-Alzheimer clinical
syndromes of frontotemporal dementia, semantic dementia and progressive non-fluent …

Frontotemporal dementia (FTD) is a clinical term encompassing dementia characterized by
the presence of two major phenotypes: 1) behavioral and personality disorder, and 2) …

Frontotemporal lobar degeneration (FTLD) recognises high familial incidence, with up to
50% of patients reported to have a family history of similar dementia. It has been reported …