Mutations in the progranulin gene (GRN) are a major cause of frontotemporal lobar
degeneration with ubiquitin-positive, tau-negative inclusions (FTLD-U) but the distinguishing …

Progranulin (PGRN) is a multifunctional protein that has attracted significant attention in the
neuroscience community following the recent discovery of PGRN mutations in some cases …

Frontotemporal lobar degeneration (FTLD) is a neurodegenerative condition characterized
by focal degeneration of the frontal and temporal lobes of the brain. Autosomal dominantly …

Objective: Loss-of-function mutations in the progranulin gene (PGRN) were identified in
frontotemporal lobar degeneration (FTLD) with ubiquitin-immunoreactive neuronal …

Frontotemporal dementia (FTD) has been linked to mutations in the progranulin gene (GRN)
that lead to progranulin (PGRN) haploinsufficiency. Thus far, our understanding of the effects …

Frontotemporal lobar degeneration (FTLD) is a neurodegenerative condition that
predominantly affects behavior, social awareness, and language. It is characterized by …

Mutations in the gene encoding granulin (HUGO gene symbol GRN, also referred to as
progranulin, PGRN), located at chromosome 17q21, were recently linked to tau‐negative …

Mutations in the progranulin (PGRN) gene have been recently demonstrated as a cause of
frontotemporal lobar degeneration (FTLD) with ubiquitin-immunoreactive neuronal inclusion …

Mutations in the gene progranulin (PGRN) were recently identified as the cause of some
forms of frontotemporal dementia with ubiquitin-positive intraneuronal inclusion pathology …

Importance Mutations in the progranulin gene are known to cause diverse clinical
syndromes, all attributed to frontotemporal lobar degeneration. We describe 2 patients with …