Loss of function mutations in progranulin cause tau-negative frontotemporal lobar
degeneration with ubiquitin-positive inclusions. A major protein component of these …

Objectives: Null mutations in progranulin (PGRN) cause ubiquitin-positive frontotemporal
dementia (FTD) linked to chromosome 17q21 (FTDU-17). Here we examined PGRN genetic …

Granulin (GRN) mutations have been identified in familial frontotemporal lobar degeneration
patients with ubiquitin pathology. GRN transcript haploinsufficiency is proposed as a …

Loss of function progranulin (GRN) mutations are a major autosomal dominant cause of
frontotemporal dementia (FTD). Patients with FTD due to GRN mutations (FTD-GRN) …

Frontotemporal lobar degeneration (FTLD) can be sporadic or familial. The genes encoding
the microtubule-associated protein tau (MAPT) and progranulin (GRN) are the most relevant …

The clinical disorders associated with frontotemporal lobar degeneration (FTLD) are
increasingly recognized as an important cause of early-onset dementia. Patients usually …

Heterozygous loss-of-function (LOF) mutations in the human progranulin gene (GRN) cause
frontotemporal lobar degeneration (FTLD) by a mechanism of haploinsufficiency. Patients …

Mutations in the progranulin gene (PGRN), on chromosome 17q21, have recently been
identified as a major cause of familial frontotemporal dementia (FTD). These cases have a …

Background Mutation in the progranulin gene (GRN) can cause frontotemporal dementia
(FTD). However, it is unclear whether some rare FTD-relatedGRNvariants are pathogenic …

Abstract Objective Mutations in the Progranulin gene (PGRN) recently have been
discovered to be associated with frontotemporal dementia (FTD) linked to 17q21 without …