Alternative splicing (AS) is a widespread process underlying the generation of transcriptomic
and proteomic diversity and is frequently misregulated in human disease. Accordingly, an …

Alternative splicing contributes to the majority of protein diversity in higher eukaryotes by
allowing one gene to generate multiple distinct protein isoforms. It adds another regulation …

Alternative splicing plays an essential role in many cellular processes and bears major
relevance in the understanding of multiple diseases, including cancer. High-throughput RNA …

Motivation: Alternative splicing (AS) is a pre-mRNA maturation process leading to the
expression of multiple mRNA variants from the same primary transcript. More than 90% of …

Alternative splicing is an important mechanism involved in health and disease. Recent work
highlights the importance of investigating genome-wide changes in splicing patterns and the …

The robust detection of disease-associated splice events from RNAseq data is challenging
due to the potential confounding effect of gene expression levels and the often limited …

Tress and colleagues proposed that only a minor fraction of splice variants detected in
transcriptome profiling data are translated and, therefore, that most splice variants have little …

Alternative splicing is widely recognized for its roles in regulating genes and creating gene
diversity. However, despite many efforts, the repertoire of gene splicing variation is still …

RNA splicing is an important driver of heterogeneity in single cells through the expression of
alternative transcripts and as a determinant of transcriptional kinetics. However, the intrinsic …

Motivation: Understanding the occurrence and regulation of alternative splicing (AS) is a key
task towards explaining the regulatory processes that shape the complex transcriptomes of …